Synthesis of 14,15-EET from Arachidonic Acid Using Urea-Hydrogen Peroxide as the Oxidant

Fuchun Xie, Bingbing X. Li, Nabil J. Alkayed, Xiangshu Xiao

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

14,15- Epoxyeicosatrienoic acid (14,15-EET) is an endogenous bioactive lipid with pharmacological benefits in multiple cardiovascular diseases. We describe here a practical synthesis of 14,15-EET from arachidonic acid using urea-hydrogen peroxide (UHP) as the oxidant.

Original languageEnglish (US)
Pages (from-to)105-110
Number of pages6
JournalSynthetic Communications
Volume45
Issue number1
DOIs
StatePublished - Jan 2 2015

Keywords

  • 14,15-EET
  • Arachidonic acid
  • epoxidation
  • urea-hydrogen peroxide

ASJC Scopus subject areas

  • Organic Chemistry

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