Synthesis of 14,15-EET from Arachidonic Acid Using Urea-Hydrogen Peroxide as the Oxidant

Fuchun Xie; Bingbing X. Li; Nabil J. Alkayed; Xiangshu Xiao

doi:10.1080/00397911.2014.956369

Synthesis of 14,15-EET from Arachidonic Acid Using Urea-Hydrogen Peroxide as the Oxidant

Fuchun Xie, Bingbing X. Li, Nabil J. Alkayed, Xiangshu Xiao

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

14,15- Epoxyeicosatrienoic acid (14,15-EET) is an endogenous bioactive lipid with pharmacological benefits in multiple cardiovascular diseases. We describe here a practical synthesis of 14,15-EET from arachidonic acid using urea-hydrogen peroxide (UHP) as the oxidant.

Original language	English (US)
Pages (from-to)	105-110
Number of pages	6
Journal	Synthetic Communications
Volume	45
Issue number	1
DOIs	https://doi.org/10.1080/00397911.2014.956369
State	Published - Jan 2 2015

Keywords

14,15-EET
Arachidonic acid
epoxidation
urea-hydrogen peroxide

ASJC Scopus subject areas

Organic Chemistry

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10.1080/00397911.2014.956369

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abstract = "14,15- Epoxyeicosatrienoic acid (14,15-EET) is an endogenous bioactive lipid with pharmacological benefits in multiple cardiovascular diseases. We describe here a practical synthesis of 14,15-EET from arachidonic acid using urea-hydrogen peroxide (UHP) as the oxidant.",

keywords = "14,15-EET, Arachidonic acid, epoxidation, urea-hydrogen peroxide",

author = "Fuchun Xie and Li, {Bingbing X.} and Alkayed, {Nabil J.} and Xiangshu Xiao",

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AU - Xie, Fuchun

AU - Li, Bingbing X.

AU - Alkayed, Nabil J.

AU - Xiao, Xiangshu

PY - 2015/1/2

Y1 - 2015/1/2

N2 - 14,15- Epoxyeicosatrienoic acid (14,15-EET) is an endogenous bioactive lipid with pharmacological benefits in multiple cardiovascular diseases. We describe here a practical synthesis of 14,15-EET from arachidonic acid using urea-hydrogen peroxide (UHP) as the oxidant.

AB - 14,15- Epoxyeicosatrienoic acid (14,15-EET) is an endogenous bioactive lipid with pharmacological benefits in multiple cardiovascular diseases. We describe here a practical synthesis of 14,15-EET from arachidonic acid using urea-hydrogen peroxide (UHP) as the oxidant.

KW - 14,15-EET

KW - Arachidonic acid

KW - epoxidation

KW - urea-hydrogen peroxide

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JF - Synthetic Communications

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Synthesis of 14,15-EET from Arachidonic Acid Using Urea-Hydrogen Peroxide as the Oxidant

Abstract

Keywords

ASJC Scopus subject areas

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