Synthesis of [125I]-, [2H]-, and [ 3H]-labeled 3-iodothyronamine (T1AM)

Motonori Miyakawa, Thomas (Tom) Scanlan

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

3-Iodothyronamine (T1AM) is a novel metabolite of thyroid hormone. In HEK-293 cells expressing an orphan G-protein coupled receptor, the trace amine receptor, T1AM, potently increased cAMP accumulation. In mice, T1AM rapidly induced hypothermia and bradycardia within minutes of administration. These results suggest the existence of a new signaling pathway, the stimulation of which leads to rapid physiological and behavioral consequences. Isotope-labeled T1AM derivatives would be useful to study the biology and pharmacology of T1AM. Herein we describe efficient syntheses of [125I]-, [2H]-, and [ 3H]-T1AM.

Original languageEnglish (US)
Pages (from-to)891-902
Number of pages12
JournalSynthetic Communications
Volume36
Issue number7
DOIs
Publication statusPublished - 2006
Externally publishedYes

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Keywords

  • 3-Iodothyronamine (TAM)
  • [I]-TAM
  • [H]-TAM
  • [H]-TAM

ASJC Scopus subject areas

  • Organic Chemistry

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