Synthesis and testing of substituted phenylthioribose analogs against Klebsiella pneumoniae

R. W. Winter; Kenneth A. Cornell; Linda L. Johnson; Michael K. Riscoe

doi:10.1016/S0960-894X(01)81020-9

Synthesis and testing of substituted phenylthioribose analogs against Klebsiella pneumoniae

R. W. Winter, Kenneth A. Cornell, Linda L. Johnson, Michael K. Riscoe

Molecular Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Halogen substituted analogs of 5-(phenylthio)ribose were synthesized and tested as inhibitors of the methylthioribose kinase-containing pathogen. Klebsiella pneumoniae. All of the compounds exhibit good activity against organism. 5-(4-Iodophenylthio)ribose demonstrated the most potent inhibitory effects with a 50% inhibitory concentration (IC₅₀) value of ^′2.5 picomolar (0.0009 ng/ml).

Original language	English (US)
Pages (from-to)	2079-2082
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	3
Issue number	10
DOIs	https://doi.org/10.1016/S0960-894X(01)81020-9
State	Published - Oct 1993

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(01)81020-9

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title = "Synthesis and testing of substituted phenylthioribose analogs against Klebsiella pneumoniae",

abstract = "Halogen substituted analogs of 5-(phenylthio)ribose were synthesized and tested as inhibitors of the methylthioribose kinase-containing pathogen. Klebsiella pneumoniae. All of the compounds exhibit good activity against organism. 5-(4-Iodophenylthio)ribose demonstrated the most potent inhibitory effects with a 50% inhibitory concentration (IC50) value of ′2.5 picomolar (0.0009 ng/ml).",

author = "Winter, {R. W.} and Cornell, {Kenneth A.} and Johnson, {Linda L.} and Riscoe, {Michael K.}",

year = "1993",

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T1 - Synthesis and testing of substituted phenylthioribose analogs against Klebsiella pneumoniae

AU - Winter, R. W.

AU - Cornell, Kenneth A.

AU - Johnson, Linda L.

AU - Riscoe, Michael K.

PY - 1993/10

Y1 - 1993/10

N2 - Halogen substituted analogs of 5-(phenylthio)ribose were synthesized and tested as inhibitors of the methylthioribose kinase-containing pathogen. Klebsiella pneumoniae. All of the compounds exhibit good activity against organism. 5-(4-Iodophenylthio)ribose demonstrated the most potent inhibitory effects with a 50% inhibitory concentration (IC50) value of ′2.5 picomolar (0.0009 ng/ml).

AB - Halogen substituted analogs of 5-(phenylthio)ribose were synthesized and tested as inhibitors of the methylthioribose kinase-containing pathogen. Klebsiella pneumoniae. All of the compounds exhibit good activity against organism. 5-(4-Iodophenylthio)ribose demonstrated the most potent inhibitory effects with a 50% inhibitory concentration (IC50) value of ′2.5 picomolar (0.0009 ng/ml).

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U2 - 10.1016/S0960-894X(01)81020-9

DO - 10.1016/S0960-894X(01)81020-9

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 10

ER -

Synthesis and testing of substituted phenylthioribose analogs against Klebsiella pneumoniae

Abstract

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