Synthesis and testing of substituted phenylthioribose analogs against Klebsiella pneumoniae

R. W. Winter, Kenneth A. Cornell, Linda L. Johnson, Michael K. Riscoe

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Halogen substituted analogs of 5-(phenylthio)ribose were synthesized and tested as inhibitors of the methylthioribose kinase-containing pathogen. Klebsiella pneumoniae. All of the compounds exhibit good activity against organism. 5-(4-Iodophenylthio)ribose demonstrated the most potent inhibitory effects with a 50% inhibitory concentration (IC50) value of 2.5 picomolar (0.0009 ng/ml).

Original languageEnglish (US)
Pages (from-to)2079-2082
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume3
Issue number10
DOIs
StatePublished - Oct 1993

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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