Synthesis and testing of substituted phenylthioribose analogs against Klebsiella pneumoniae

R. W. Winter, Kenneth A. Cornell, Linda L. Johnson, Michael Riscoe

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Halogen substituted analogs of 5-(phenylthio)ribose were synthesized and tested as inhibitors of the methylthioribose kinase-containing pathogen. Klebsiella pneumoniae. All of the compounds exhibit good activity against organism. 5-(4-Iodophenylthio)ribose demonstrated the most potent inhibitory effects with a 50% inhibitory concentration (IC50) value of 2.5 picomolar (0.0009 ng/ml).

Original languageEnglish (US)
Pages (from-to)2079-2082
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume3
Issue number10
DOIs
StatePublished - 1993

Fingerprint

Ribose
Klebsiella pneumoniae
Inhibitory Concentration 50
Halogens
Testing
Pathogens
Phosphotransferases

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Synthesis and testing of substituted phenylthioribose analogs against Klebsiella pneumoniae. / Winter, R. W.; Cornell, Kenneth A.; Johnson, Linda L.; Riscoe, Michael.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 3, No. 10, 1993, p. 2079-2082.

Research output: Contribution to journalArticle

Winter, R. W. ; Cornell, Kenneth A. ; Johnson, Linda L. ; Riscoe, Michael. / Synthesis and testing of substituted phenylthioribose analogs against Klebsiella pneumoniae. In: Bioorganic and Medicinal Chemistry Letters. 1993 ; Vol. 3, No. 10. pp. 2079-2082.
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