Abstract
Ten aryl‐carbohydrate ligands have been synthesized that potentially increase the tumor retention and decrease the deiodination of iodinated monoclonal antibodies used in the imaging and treatment of cancer. The compounds were synthesized via reductive amination reactions, purified with cation exchange chromatography, and characterized using 1H and 13C NMR. These compounds were then radioiodinated to assess their iodination characteristics, for subsequent experiments involving attachment to monoclonal antibodies.
Original language | English (US) |
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Pages (from-to) | 497-509 |
Number of pages | 13 |
Journal | Journal of Labelled Compounds and Radiopharmaceuticals |
Volume | 28 |
Issue number | 5 |
DOIs | |
State | Published - May 1990 |
Externally published | Yes |
ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry
- Radiology Nuclear Medicine and imaging
- Drug Discovery
- Spectroscopy
- Organic Chemistry