Synthesis and radioiodination of ten aryl‐carbohydrate compounds for labeling monoclonal antibodies

S. D. Warren, S. A. Ali, K. Y. Richter, K. A. Krohn

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Ten aryl‐carbohydrate ligands have been synthesized that potentially increase the tumor retention and decrease the deiodination of iodinated monoclonal antibodies used in the imaging and treatment of cancer. The compounds were synthesized via reductive amination reactions, purified with cation exchange chromatography, and characterized using 1H and 13C NMR. These compounds were then radioiodinated to assess their iodination characteristics, for subsequent experiments involving attachment to monoclonal antibodies.

Original languageEnglish (US)
Pages (from-to)497-509
Number of pages13
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume28
Issue number5
DOIs
StatePublished - May 1990

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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