Synthesis and radiobiological applications of [35S]l-homocysteine thiolactone

Zdenka Grunbaum, Keith Kroll, Janet L. Greene, Janet S. Rasey, Kenneth Krohn

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

[35S]l-Homocysteine thiolactone ([35S]l-HCTL) was synthesized and its biodistribution evaluated as a potential brain radioprotective agent and as a tissue hypoxia marker. Drug uptake in mouse brain exceeded that in s.c. tumor 3 h post injection only. Multiple indicator dilution experiments in the rabbit heart indicate that membrane permeability of [35S]l-HCTL does not limit its usefulness as a hypoxia marker. In addition, a positive correlation was observed between regional coronary blood flow and myocardial content of [35S]adenosylhomocysteine formed from [35S]homocysteine and adenosine.

Original languageEnglish (US)
Pages (from-to)473-478
Number of pages6
JournalInternational Journal of Radiation Applications and Instrumentation.
Volume17
Issue number5
DOIs
StatePublished - 1990
Externally publishedYes

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Radiation-Protective Agents
Regional Blood Flow
Brain
Homocysteine
Adenosine
Permeability
Rabbits
Injections
Membranes
Pharmaceutical Preparations
Neoplasms
homocysteine thiolactone
Hypoxia

ASJC Scopus subject areas

  • Medicine(all)
  • Cancer Research
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Synthesis and radiobiological applications of [35S]l-homocysteine thiolactone. / Grunbaum, Zdenka; Kroll, Keith; Greene, Janet L.; Rasey, Janet S.; Krohn, Kenneth.

In: International Journal of Radiation Applications and Instrumentation., Vol. 17, No. 5, 1990, p. 473-478.

Research output: Contribution to journalArticle

Grunbaum, Zdenka ; Kroll, Keith ; Greene, Janet L. ; Rasey, Janet S. ; Krohn, Kenneth. / Synthesis and radiobiological applications of [35S]l-homocysteine thiolactone. In: International Journal of Radiation Applications and Instrumentation. 1990 ; Vol. 17, No. 5. pp. 473-478.
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