Abstract
In this study, the effect of fluorine upon the heme-binding ability of the xanthone nucleus was investigated for 3,6-bis-(ω-N,N-diethylaminoamyloxy)-4,5-difluoroxanthone (F2C5). 2-Fluoro-1,3-dimethoxybenzene was prepared by a new, improved method and used to build up the xanthone nucleus. The interaction of F2C5 with heme was investigated by UV-vis, 1H NMR, and 19F NMR spectroscopy. For the first time, NMR studies for the heme-drug interactions are carried out at pH 5.0, physiological for the acidic food vacuole of the malaria parasite.
Original language | English (US) |
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Pages (from-to) | 1174-1183 |
Number of pages | 10 |
Journal | Bioorganic and Medicinal Chemistry |
Volume | 16 |
Issue number | 3 |
DOIs | |
State | Published - Feb 1 2008 |
Keywords
- Fluoroxanthone
- Heme-binding
- Malaria
- Spectroscopic investigation of binding
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry