Synthesis and Evaluation of New Bifunctional Chelators with Phosphonic Acid Arms for Gallium-68 Based PET Imaging in Melanoma

Medicine & Life Sciences

• Gallium-68 100%
• phosphonic acid 95%
• Chelating Agents 65%
• Integrin alpha4beta1 55%
• Arm 51%
• Melanoma 48%
• Positron Emission Tomography Computed Tomography 42%
• Very Late Antigen Receptors 38%
• Density Functional Theory 34%
• Peptidomimetics 28%
• Radiopharmaceuticals 23%
• Heterografts 17%
• Temperature 14%
• Ligands 13%
• Neoplasms 12%
• Serum 8%
• In Vitro Techniques 8%

Engineering & Materials Science

• Gallium 83%
• Positron emission tomography 54%
• Acids 53%
• Antigens 52%
• Imaging techniques 44%
• Tumors 40%
• Tomography 37%
• Heterografts 36%
• Density functional theory 29%
• Biomolecules 27%
• Ligands 25%
• Functional groups 25%
• Temperature 7%

Chemical Compounds

• Phosphonic Acid 67%
• Radiopharmaceutical 24%
• Peptidomimetic 23%
• Density Functional Theory 12%
• Ligand 8%
• pH Value 8%
• Application 6%