Synthesis and applications of ionic liquids as pharmaceutical materials

Research output: Chapter in Book/Report/Conference proceedingChapter


Ionic liquids (ILs) consist of ions and remain liquid at temperatures below 100°C. The so-called room temperature ionic liquids (RTILs) are most suitable as solvents for chemical reactions and other applications. Comparing with conventional organic solvents, ILs have many favorable properties, such as very low vapor pressure, a wide liquid range, low flammability, high ionic conductivity, high thermal conductivity, high dissolution power toward many substrates, high thermal and chemical stability, and a wide electrochemical potential window. Due to these unique properties, ILs have been widely recognized as solvents or reagents in a variety of applications, including organic catalysis, inorganic synthesis, biocatalysis, polymerization, and engineering fluids. Typical IL cations are nitrogen containing (such as alkylammonium, N, N′-dialkylimidazolium, N-alkylpyridinium, and pyrrolidinium) or phosphorous containing (such as alkylphosphonium). The common choices of anions include halides, BF4, PF6 , CH3CO2 , CF3CO2 , NO3 , Tf2N (i.e., (CF3SO2)2N), [RSO4], [R2PO4], etc. Some typical cations and anions are illustrated in Scheme 5.1a.

Original languageEnglish (US)
Title of host publicationEnvironmentally Friendly Syntheses Using Ionic Liquids
PublisherCRC Press
Number of pages22
ISBN (Electronic)9781466579774
ISBN (Print)9781466579767
StatePublished - Jan 1 2014
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)


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