Synthesis and anticancer activity of 13-membered cyclic enediynes

Mukul Sharma, Mukesh C. Joshi, Vineet Kumar, Sanjay V. Malhotra, Diwan S. Rawat

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

We herein describe the synthesis of 15 novel 13-membered cyclic enediyne derivatives using simple and straightforward approach. Representative examples were screened for their anticancer activities on 60 different human tumor cell lines representing various histologies viz. leukemia, melanoma, and cancers of lung, colon, kidney, ovary, breast, prostate, and central nervous system. The enediyne derivatives with halogen substitutions, especially fluorides were found to be active against most of the cell lines. The initial results indicates marginal to good inhibition for the growth of tumor cells for several cell lines, which shows the potential of these class of compound towards anticancer application. 15 novel 13-membered cyclic enediyne derivatives using a simple and straightforward approach are synthesized. The initial results show the potential of this class of compounds towards anticancer application.

Original languageEnglish (US)
Pages (from-to)564-571
Number of pages8
JournalArchiv der Pharmazie
Volume344
Issue number9
DOIs
StatePublished - Sep 2011
Externally publishedYes

Keywords

  • Anticancer
  • Cell lines
  • Enediyne

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery

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