Syndromes of Thrombotic Microangiopathy

Joseph J. Shatzel, Jason Taylor

Research output: Contribution to journalReview article

21 Scopus citations

Abstract

Thrombotic thrombocytopenia purpura (TTP) and the hemolytic uremic syndrome (HUS) are rare thrombotic microangiopathies that can be rapidly fatal. Although the acquired versions of TTP and HUS are generally highest on this broad differential, multiple rarer entities can produce a clinical picture similar to TTP/HUS, including microangiopathic hemolysis, renal failure, and neurologic compromise. More recent analysis has discovered a host of genetic factors that can produce microangiopathic hemolytic syndromes. This article discusses the current understanding of thrombotic microangiopathy and outlines the pathophysiology and causative agents associated with each distinct syndrome as well as the most accepted treatments.

Original languageEnglish (US)
Pages (from-to)395-415
Number of pages21
JournalMedical Clinics of North America
Volume101
Issue number2
DOIs
StatePublished - Mar 1 2017

Keywords

  • Atypical hemolytic uremic syndrome (aHUS)
  • Hemolytic uremic syndrome (HUS)
  • Microangiopathic hemolytic anemia (MAHA)
  • Pregnancy induced microangiopathic hemolytic anemia
  • Thrombotic thrombocytopenic purpura (TTP)
  • Transplant induced microangiopathic hemolytic anemia

ASJC Scopus subject areas

  • Medicine(all)

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