Synchronous neural interactions assessed by magnetoencephalography: A functional biomarker for brain disorders

Apostolos P. Georgopoulos, Elissaios Karageorgiou, Arthur C. Leuthold, Scott M. Lewis, Joshua K. Lynch, Aurelio A. Alonso, Zaheer Aslam, Adam F. Carpenter, Angeliki Georgopoulos, Laura S. Hemmy, Ioannis G. Koutlas, Frederick J.P. Langheim, J. Riley McCarten, Susan E. McPherson, José V. Pardo, Patricia J. Pardo, Gareth J. Parry, Susan J. Rottunda, Barbara M. Segal, Scott R. SponheimJohn J. Stanwyck, Massoud Stephane, Joseph J. Westermeyer

    Research output: Contribution to journalArticle

    74 Scopus citations

    Abstract

    We report on a test to assess the dynamic brain function at high temporal resolution using magnetoencephalography (MEG). The essence of the test is the measurement of the dynamic synchronous neural interactions, an essential aspect of the brain function. MEG signals were recorded from 248 axial gradiometers while 142 human subjects fixated a spot of light for 45-60 s. After fitting an autoregressive integrative moving average (ARIMA) model and taking the stationary residuals, all pairwise, zero-lag, partial cross-correlations (PCCij0) and their z-transforms (zij 0) between i and j sensors were calculated, providing estimates of the strength and sign (positive, negative) of direct synchronous coupling at 1 ms temporal resolution. We found that subsets of zij0 successfully classified individual subjects to their respective groups (multiple sclerosis, Alzheimer's disease, schizophrenia, Sjögren's syndrome, chronic alcoholism, facial pain, healthy controls) and gave excellent external cross-validation results.

    Original languageEnglish (US)
    Pages (from-to)349-355
    Number of pages7
    JournalJournal of Neural Engineering
    Volume4
    Issue number4
    DOIs
    StatePublished - Dec 1 2007

    ASJC Scopus subject areas

    • Biomedical Engineering
    • Cellular and Molecular Neuroscience

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    Georgopoulos, A. P., Karageorgiou, E., Leuthold, A. C., Lewis, S. M., Lynch, J. K., Alonso, A. A., Aslam, Z., Carpenter, A. F., Georgopoulos, A., Hemmy, L. S., Koutlas, I. G., Langheim, F. J. P., McCarten, J. R., McPherson, S. E., Pardo, J. V., Pardo, P. J., Parry, G. J., Rottunda, S. J., Segal, B. M., ... Westermeyer, J. J. (2007). Synchronous neural interactions assessed by magnetoencephalography: A functional biomarker for brain disorders. Journal of Neural Engineering, 4(4), 349-355. https://doi.org/10.1088/1741-2560/4/4/001