Synaptic potentials in locus coeruleus neurons in brain slices

John Williams, D. H. Bobker, G. C. Harris

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Neurons of the locus coeruleus (LC) fire action potentials spontaneously in vitro in the absence of any stimulation. This spontaneous activity is thought to arise from intrinsic membrane properties that include a balance between at least two ion conductances. One is a persistent inward sodium current that is active near the threshold for action potential generation. The second is a calcium-dependent potassium current that is activated following the entry of calcium during the action potential, is responsible for the after-hyperpolarization following the action potential, and decays over a period of 1-2 sec following the action potential. The spontaneous activity of LC neurons can be altered by both excitatory and inhibitory synaptic inputs. One excitatory input has been described that is mediated by glutamate receptors of both the non-NMDA and NMDA subtypes. Inhibitory synaptic potentials include those mediated by GABA (acting on GABA(A)-receptors), glycine (acting on a strychnine-sensitive receptor) and noradrenaline (acting on α2-adrenoceptors). The presence of synaptic potentials mediated by these transmitters, studied in vitro, correlate with studies made in vivo and with histochemical identification of synaptic inputs to the locus coeruleus.

Original languageEnglish (US)
Pages (from-to)167-172
Number of pages6
JournalProgress in Brain Research
Volume88
StatePublished - 1991

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Synaptic Potentials
Locus Coeruleus
Action Potentials
Neurons
Brain
Calcium
Glutamate Receptors
N-Methylaspartate
GABA-A Receptors
Glycine
gamma-Aminobutyric Acid
Adrenergic Receptors
Norepinephrine
Potassium
Sodium
Ions
Membranes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Synaptic potentials in locus coeruleus neurons in brain slices. / Williams, John; Bobker, D. H.; Harris, G. C.

In: Progress in Brain Research, Vol. 88, 1991, p. 167-172.

Research output: Contribution to journalArticle

Williams, John ; Bobker, D. H. ; Harris, G. C. / Synaptic potentials in locus coeruleus neurons in brain slices. In: Progress in Brain Research. 1991 ; Vol. 88. pp. 167-172.
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