Synaptic plasticity in inhibitory neurons of the auditory brainstem

Kevin J. Bender, Laurence O. Trussell

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

There is a growing appreciation of synaptic plasticity in the early levels of auditory processing, and particularly of its role in inhibitory circuits. Synaptic strength in auditory brainstem and midbrain is sensitive to standard protocols for induction of long-term depression, potentiation, and spike-timing-dependent plasticity. Differential forms of plasticity are operative at synapses onto inhibitory versus excitatory neurons within a circuit, and together these could serve to tune circuits involved in sound localization or multisensory integration. Such activity-dependent control of synaptic function in inhibitory neurons may also be expressed after hearing loss and could underlie persistent neuronal activity in patients with tinnitus. This article is part of a Special Issue entitled 'Synaptic Plasticity & Interneurons'.

Original languageEnglish (US)
Pages (from-to)774-779
Number of pages6
JournalNeuropharmacology
Volume60
Issue number5
DOIs
StatePublished - Apr 1 2011

Keywords

  • Auditory
  • Cochlear nucleus
  • Deafness
  • GABA
  • Glycine
  • MNTB
  • Plasticity

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

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