Synaptic mechanisms for coding timing in auditory neurons

Research output: Contribution to journalArticle

317 Citations (Scopus)

Abstract

Neurons in the cochlear ganglion and auditory brain stem nuclei preserve the relative timing of action potentials passed through sequential synaptic levels. To accomplish this task, these neurons have unique morphological and biophysical specializations in axons, dendrites, and nerve terminals. At the membrane level, these adaptations include low-threshold, voltage-gated potassium channels and unusually rapid-acting transmitter-gated channels, which govern how quickly and reliably action potential threshold is reached during a synaptic response. Some nerve terminals are remarkably large and release large amounts of excitatory neurotransmitter. The high output of transmitter at these terminals can lead to synaptic depression, which may itself be regulated by presynaptic transmitter receptors. The way in which these different cellular mechanisms are employed varies in different cell types and circuits and reflects refinements suited to different aspects of acoustic processing.

Original languageEnglish (US)
Pages (from-to)477-496
Number of pages20
JournalAnnual Review of Physiology
Volume61
DOIs
StatePublished - 1999
Externally publishedYes

Fingerprint

Action Potentials
Spiral Ganglion
Presynaptic Receptors
Voltage-Gated Potassium Channels
Neurons
Cochlea
Dendrites
Acoustics
Brain Stem
Neurotransmitter Agents
Axons
Membranes

Keywords

  • Glutamate receptors
  • Plasticity
  • Potassium channels
  • Synapses

ASJC Scopus subject areas

  • Physiology

Cite this

Synaptic mechanisms for coding timing in auditory neurons. / Trussell, Laurence.

In: Annual Review of Physiology, Vol. 61, 1999, p. 477-496.

Research output: Contribution to journalArticle

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