Synaptic and morphological neuroadaptations in the putamen associated with long-term, relapsing alcohol drinking in primates

Verginia Cuzon Carlson, Gail K. Seabold, Christa Helms, Natasha Garg, Misa Odagiri, Andrew R. Rau, James Daunais, Veronica A. Alvarez, David M. Lovinger, Kathleen (Kathy) Grant

    Research output: Contribution to journalArticle

    72 Citations (Scopus)

    Abstract

    Alcoholism and alcohol use disorders are characterized by several months to decades of heavy and problematic drinking, interspersed with periods of abstinence and relapse to heavy drinking. This alcohol-drinking phenotype was modeled using macaque monkeys to explore neuronal adaptations in the striatum, a brain region controlling habitual behaviors. Prolonged drinking with repeated abstinence narrowed the variability in daily intake, increased the amount of ethanol consumed in bouts, and led to higher blood ethanol concentrations more than twice the legal intoxication limit. After the final abstinence period of this extensive drinking protocol, we found a selective increase in dendritic spine density and enhanced glutamatergic transmission in the putamen, but not in the caudate nucleus. Intrinsic excitability of medium-sized spiny neurons was also enhanced in the putamen of alcohol-drinking monkeys in comparison with non-drinkers, and GABAeric transmission was selectively suppressed in the putamen of heavy drinkers. These morphological and physiological changes indicate a shift in the balance of inhibitory/excitatory transmission that biases the circuit toward an enduring increase in synaptic activation of putamen output as a consequence of prolonged heavy drinking/relapse. The resultant potential for increased putamen activation may underlie an alcohol-drinking phenotype of regulated drinking and sustained intoxication.

    Original languageEnglish (US)
    Pages (from-to)2513-2528
    Number of pages16
    JournalNeuropsychopharmacology
    Volume36
    Issue number12
    DOIs
    StatePublished - Nov 2011

    Fingerprint

    Putamen
    Alcohol Drinking
    Primates
    Drinking
    Haplorhini
    Ethanol
    Phenotype
    Recurrence
    Dendritic Spines
    Caudate Nucleus
    Macaca
    Alcoholism
    Alcohols
    Neurons
    Brain

    Keywords

    • alcohol
    • caudate/putamen
    • GABAergictransmission
    • glutamatergic transmission
    • self-administration monkeys
    • synaptic morphology

    ASJC Scopus subject areas

    • Pharmacology
    • Psychiatry and Mental health

    Cite this

    Synaptic and morphological neuroadaptations in the putamen associated with long-term, relapsing alcohol drinking in primates. / Cuzon Carlson, Verginia; Seabold, Gail K.; Helms, Christa; Garg, Natasha; Odagiri, Misa; Rau, Andrew R.; Daunais, James; Alvarez, Veronica A.; Lovinger, David M.; Grant, Kathleen (Kathy).

    In: Neuropsychopharmacology, Vol. 36, No. 12, 11.2011, p. 2513-2528.

    Research output: Contribution to journalArticle

    Cuzon Carlson, Verginia ; Seabold, Gail K. ; Helms, Christa ; Garg, Natasha ; Odagiri, Misa ; Rau, Andrew R. ; Daunais, James ; Alvarez, Veronica A. ; Lovinger, David M. ; Grant, Kathleen (Kathy). / Synaptic and morphological neuroadaptations in the putamen associated with long-term, relapsing alcohol drinking in primates. In: Neuropsychopharmacology. 2011 ; Vol. 36, No. 12. pp. 2513-2528.
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