TY - JOUR
T1 - Synaptic activation of presynaptic kainate receptors on hippocampal mossy fiber synapses
AU - Schmitz, Dietmar
AU - Frerking, Matthew
AU - Nicoll, Roger A.
N1 - Funding Information:
We thank U. Heinemann for his help with the ion-sensitive electrode experiments, Eric Schnell for his input during this study, and Helen Czerwonka for expert secretarial assistance. D. S. is supported by a grant from the Deutsche Forschungsgemeinschaft (Emmy-Noether-Programm). R. A. N. is supported by grants from the National Institutes of Health and Bristol-Myers Squibb. R. A. N. is a member of the Keck Center for Integrative Neuroscience and the Silvio Conte Center for Neuroscience Research.
PY - 2000
Y1 - 2000
N2 - Kainate receptors (KARs) are a poorly understood family of ionotropic glutamate receptors. A role for these receptors in the presynaptic control of transmitter release has been proposed but remains controversial. Here, KAR agonists are shown to enhance fiber excitability, and a number of experiments show that this is a direct effect of KARs on the presynaptic fibers. In addition, KAR activation inhibits evoked transmitter release from mossy fiber synapses. Synaptic release of glutamate from either neighboring mossy fiber synapses or associational/commisural (A/C) synapses results in the activation of these presynaptic ionotropic KARs. These results, along with previous studies, indicate that KARs, through the endogenous release of glutamate, mediate excitatory postsynaptic potentials (EPSPs), alter presynaptic excitability, and modulate transmitter release.
AB - Kainate receptors (KARs) are a poorly understood family of ionotropic glutamate receptors. A role for these receptors in the presynaptic control of transmitter release has been proposed but remains controversial. Here, KAR agonists are shown to enhance fiber excitability, and a number of experiments show that this is a direct effect of KARs on the presynaptic fibers. In addition, KAR activation inhibits evoked transmitter release from mossy fiber synapses. Synaptic release of glutamate from either neighboring mossy fiber synapses or associational/commisural (A/C) synapses results in the activation of these presynaptic ionotropic KARs. These results, along with previous studies, indicate that KARs, through the endogenous release of glutamate, mediate excitatory postsynaptic potentials (EPSPs), alter presynaptic excitability, and modulate transmitter release.
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U2 - 10.1016/S0896-6273(00)00040-4
DO - 10.1016/S0896-6273(00)00040-4
M3 - Article
C2 - 10985352
AN - SCOPUS:0033679123
SN - 0896-6273
VL - 27
SP - 327
EP - 338
JO - Neuron
JF - Neuron
IS - 2
ER -