Synaptic activation of presynaptic kainate receptors on hippocampal mossy fiber synapses

Dietmar Schmitz, Matthew Frerking, Roger A. Nicoll

Research output: Contribution to journalArticle

162 Citations (Scopus)

Abstract

Kainate receptors (KARs) are a poorly understood family of ionotropic glutamate receptors. A role for these receptors in the presynaptic control of transmitter release has been proposed but remains controversial. Here, KAR agonists are shown to enhance fiber excitability, and a number of experiments show that this is a direct effect of KARs on the presynaptic fibers. In addition, KAR activation inhibits evoked transmitter release from mossy fiber synapses. Synaptic release of glutamate from either neighboring mossy fiber synapses or associational/commisural (A/C) synapses results in the activation of these presynaptic ionotropic KARs. These results, along with previous studies, indicate that KARs, through the endogenous release of glutamate, mediate excitatory postsynaptic potentials (EPSPs), alter presynaptic excitability, and modulate transmitter release.

Original languageEnglish (US)
Pages (from-to)327-338
Number of pages12
JournalNeuron
Volume27
Issue number2
StatePublished - 2000
Externally publishedYes

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Hippocampal Mossy Fibers
Presynaptic Receptors
Kainic Acid Receptors
Synapses
Glutamic Acid
Ionotropic Glutamate Receptors
Excitatory Postsynaptic Potentials

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Schmitz, D., Frerking, M., & Nicoll, R. A. (2000). Synaptic activation of presynaptic kainate receptors on hippocampal mossy fiber synapses. Neuron, 27(2), 327-338.

Synaptic activation of presynaptic kainate receptors on hippocampal mossy fiber synapses. / Schmitz, Dietmar; Frerking, Matthew; Nicoll, Roger A.

In: Neuron, Vol. 27, No. 2, 2000, p. 327-338.

Research output: Contribution to journalArticle

Schmitz, D, Frerking, M & Nicoll, RA 2000, 'Synaptic activation of presynaptic kainate receptors on hippocampal mossy fiber synapses', Neuron, vol. 27, no. 2, pp. 327-338.
Schmitz, Dietmar ; Frerking, Matthew ; Nicoll, Roger A. / Synaptic activation of presynaptic kainate receptors on hippocampal mossy fiber synapses. In: Neuron. 2000 ; Vol. 27, No. 2. pp. 327-338.
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