Synapse-specific opioid modulation of thalamo-cortico-striatal circuits

William T. Birdsong, Bart C. Jongbloets, Kim A. Engeln, Dong Wang, Grégory Scherrer, Tianyi Mao

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The medial thalamus (MThal), anterior cingulate cortex (ACC) and striatum play important roles in affective-motivational pain processing and reward learning. Opioids affect both pain and reward through uncharacterized modulation of this circuitry. This study examined opioid actions on glutamate transmission between these brain regions in mouse. Mu-opioid receptor (MOR) agonists potently inhibited MThal inputs without affecting ACC inputs to individual striatal medium spiny neurons (MSNs). MOR activation also inhibited MThal inputs to the pyramidal neurons in the ACC. In contrast, delta-opioid receptor (DOR) agonists disinhibited ACC pyramidal neuron responses to MThal inputs by suppressing local feed-forward GABA signaling from parvalbumin-positive interneurons. As a result, DOR activation in the ACC facilitated poly-synaptic (thalamo-cortico-striatal) excitation of MSNs by MThal inputs. These results suggest that opioid effects on pain and reward may be shaped by the relative selectivity of opioid drugs to the specific circuit components.

Original languageEnglish (US)
Article numbere41356
JournaleLife
Volume8
DOIs
StatePublished - May 1 2019

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Corpus Striatum
Gyrus Cinguli
Thalamus
Synapses
Opioid Analgesics
Neurons
Modulation
delta Opioid Receptor
Reward
Networks (circuits)
mu Opioid Receptor
Pyramidal Cells
Pain
Chemical activation
Parvalbumins
gamma-Aminobutyric Acid
Glutamic Acid
Interneurons
Brain
Learning

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Birdsong, W. T., Jongbloets, B. C., Engeln, K. A., Wang, D., Scherrer, G., & Mao, T. (2019). Synapse-specific opioid modulation of thalamo-cortico-striatal circuits. eLife, 8, [e41356]. https://doi.org/10.7554/eLife.45146

Synapse-specific opioid modulation of thalamo-cortico-striatal circuits. / Birdsong, William T.; Jongbloets, Bart C.; Engeln, Kim A.; Wang, Dong; Scherrer, Grégory; Mao, Tianyi.

In: eLife, Vol. 8, e41356, 01.05.2019.

Research output: Contribution to journalArticle

Birdsong, WT, Jongbloets, BC, Engeln, KA, Wang, D, Scherrer, G & Mao, T 2019, 'Synapse-specific opioid modulation of thalamo-cortico-striatal circuits', eLife, vol. 8, e41356. https://doi.org/10.7554/eLife.45146
Birdsong WT, Jongbloets BC, Engeln KA, Wang D, Scherrer G, Mao T. Synapse-specific opioid modulation of thalamo-cortico-striatal circuits. eLife. 2019 May 1;8. e41356. https://doi.org/10.7554/eLife.45146
Birdsong, William T. ; Jongbloets, Bart C. ; Engeln, Kim A. ; Wang, Dong ; Scherrer, Grégory ; Mao, Tianyi. / Synapse-specific opioid modulation of thalamo-cortico-striatal circuits. In: eLife. 2019 ; Vol. 8.
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