@article{1d2f8a7b21c44ad0952381a2efab7650,
title = "Synapse-specific opioid modulation of thalamo-cortico-striatal circuits",
abstract = "The medial thalamus (MThal), anterior cingulate cortex (ACC) and striatum play important roles in affective-motivational pain processing and reward learning. Opioids affect both pain and reward through uncharacterized modulation of this circuitry. This study examined opioid actions on glutamate transmission between these brain regions in mouse. Mu-opioid receptor (MOR) agonists potently inhibited MThal inputs without affecting ACC inputs to individual striatal medium spiny neurons (MSNs). MOR activation also inhibited MThal inputs to the pyramidal neurons in the ACC. In contrast, delta-opioid receptor (DOR) agonists disinhibited ACC pyramidal neuron responses to MThal inputs by suppressing local feed-forward GABA signaling from parvalbumin-positive interneurons. As a result, DOR activation in the ACC facilitated poly-synaptic (thalamo-cortico-striatal) excitation of MSNs by MThal inputs. These results suggest that opioid effects on pain and reward may be shaped by the relative selectivity of opioid drugs to the specific circuit components.",
author = "Birdsong, {William T.} and Jongbloets, {Bart C.} and Engeln, {Kim A.} and Dong Wang and Gr{\'e}gory Scherrer and Tianyi Mao",
note = "Funding Information: We would like to thank Dr. John Williams for providing guidance and financial support to WTB (NIH R01DA08136), and Dr. Emmeke Aarts and Sheila Markwardt MPH for providing guidance and comments on the statistical analyses. We thank Drs. John Williams, Haining Zhong, and Brooks Robinson for comments to the manuscript. We thank Sweta Adhikary for assistance with retrobead cell counting. This work was supported by NIH grants R01DA042779 (WTB), R01DA044481 (GS), R01NS106301 (GS), R01NS081071 (TM) and U01NS094247 (TM), R01NS104944 (TM), the Department of Defense Neurosensory Award MR130053 (GS) and the New York Stem Cell Foundation (GS). GS is a New York Stem Cell Foundation - Robertson Investigator. Funding Information: National Institute of Neurological Disorders and StrokeR01NS081071 Tianyi Mao New York Stem Cell Foundation Gregory Scherrer National Institute on Drug AbuseR01DA042779 William T Birdsong National Institute on Drug Abuse R01DA044481 Gregory Scherrer National Institute on Drug AbuseR01NS106301 Gregory Scherrer National Institute of Neurological Disorders and StrokeR01NS104944 Tianyi Mao National Institute of Neurological Disorders and Stroke U01NS094247 Tianyi Mao The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. Publisher Copyright: {\textcopyright} Birdsong et al.",
year = "2019",
month = may,
doi = "10.7554/eLife.45146",
language = "English (US)",
volume = "8",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications",
}