Twenty‐nine female patients with fibromyalgia were questioned about symptoms of cold intolerance and Raynaud's syndrome; objective documentation of cold‐induced vasospasm was obtained by a Nielsen test. Twelve patients (41%) had abnormal Nielsen test results, and 11 patients (38%) had elevated levels of platelet α2‐adrenergic receptors. There was a positive correlation between the percentage of change in finger systolic pressure on cooling (Nielsen test) and the number of α2‐adrenergic receptors. There was poor correlation between Raynaud's syndrome symptoms and an abnormal Nielsen test result. Digital photoplethysmography showed a normal waveform in 2 of 3 patients. We hypothesize that a subgroup of patients with fibromyalgia syndrome have an up‐regulation of α2‐adrenergic receptors as a cause of their exaggerated reaction to cold.
|Original language||English (US)|
|Number of pages||6|
|Journal||Arthritis & Rheumatism|
|State||Published - Mar 1991|
ASJC Scopus subject areas
- Immunology and Allergy
- Pharmacology (medical)