Symmetry breakage in the vertebrate embryo

When does it happen and how does it work?

Martin Blum, Axel Schweickert, Philipp Vick, Christopher V E Wright, Michael Danilchik

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Asymmetric development of the vertebrate embryo has fascinated embryologists for over a century. Much has been learned since the asymmetric Nodal signaling cascade in the left lateral plate mesoderm was detected, and began to be unraveled over the past decade or two. When and how symmetry is initially broken, however, has remained a matter of debate. Two essentially mutually exclusive models prevail. Cilia-driven leftward flow of extracellular fluids occurs in mammalian, fish and amphibian embryos. A great deal of experimental evidence indicates that this flow is indeed required for symmetry breaking. An alternative model has argued, however, that flow simply acts as an amplification step for early asymmetric cues generated by ion flux during the first cleavage divisions. In this review we critically evaluate the experimental basis of both models. Although a number of open questions persist, the available evidence is best compatible with flow-based symmetry breakage as the archetypical mode of symmetry breakage.

Original languageEnglish (US)
Pages (from-to)109-123
Number of pages15
JournalDevelopmental Biology
Volume393
Issue number1
DOIs
StatePublished - Sep 1 2014

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Cilia
Extracellular Fluid
Amphibians
Mesoderm
Embryonic Development
Cues
Vertebrates
Fishes
Embryonic Structures
Ions

Keywords

  • Cilia
  • Ion-flux model
  • Left-right asymmetry
  • Leftward flow
  • Symmetry breakage

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology
  • Molecular Biology

Cite this

Symmetry breakage in the vertebrate embryo : When does it happen and how does it work? / Blum, Martin; Schweickert, Axel; Vick, Philipp; Wright, Christopher V E; Danilchik, Michael.

In: Developmental Biology, Vol. 393, No. 1, 01.09.2014, p. 109-123.

Research output: Contribution to journalArticle

Blum, Martin ; Schweickert, Axel ; Vick, Philipp ; Wright, Christopher V E ; Danilchik, Michael. / Symmetry breakage in the vertebrate embryo : When does it happen and how does it work?. In: Developmental Biology. 2014 ; Vol. 393, No. 1. pp. 109-123.
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