Switching patients in the age of long-acting recombinant products?

Miguel Escobar, Elena Santagostino, Maria Elisa Mancuso, Michiel Coppens, Vinod Balasa, Jason A. Taylor, Alfonso Iorio, Claude Negrier

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Introduction: Prophylaxis with factor replacement therapy is the gold standard for the treatment of hemophilia, but this often requires frequent infusions. A number of long-acting factor products have been developed to reduce the burden on patients. Areas covered: This is an overview of information presented at two symposia held at the World Federation of Hemophilia and International Society on Thrombosis and Haemostasis–Scientific and Standardization Committee annual meetings. The pharmacokinetic, safety and efficacy data for long-acting recombinant products are reviewed, with a focus on recombinant factor IX albumin fusion protein (rIX-FP) and rVIII-SingleChain. This overview also provides a guide for managing a patient’s switch to long-acting products. Expert opinion: Long-acting products may allow patients to maintain or decrease bleeding rates whilst increasing their dosing interval, which may in turn reduce the burden on patients and caregivers. When switching patients to long-acting products health-care professionals should provide balanced and thorough education to the patient, whilst supporting their emotional well-being. Regimens should address patients’ needs and goals but should also be guided by clinical phenotype and pharmacokinetic assessment. Follow-up should assess safety concerns, bleeding rates, joint health and the impact of the regimen on patients’ lifestyle.

Original languageEnglish (US)
Pages (from-to)1-13
Number of pages13
JournalExpert Review of Hematology
Volume12
Issue numbersup1
DOIs
StatePublished - Jan 14 2019

Keywords

  • Hemophilia
  • meeting report
  • personalized treatment
  • pharmacokinetics

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Switching patients in the age of long-acting recombinant products?'. Together they form a unique fingerprint.

  • Cite this

    Escobar, M., Santagostino, E., Mancuso, M. E., Coppens, M., Balasa, V., Taylor, J. A., Iorio, A., & Negrier, C. (2019). Switching patients in the age of long-acting recombinant products? Expert Review of Hematology, 12(sup1), 1-13. https://doi.org/10.1080/17474086.2018.1564032