Sustained Weight Loss with Vagal Nerve Blockade but Not with Sham: 18-Month Results of the ReCharge Trial

Scott A. Shikora, Bruce Wolfe, Caroline M. Apovian, Mehran Anvari, David B. Sarwer, Robert D. Gibbons, Sayeed Ikramuddin, Christopher J. Miller, Mark B. Knudson, Katherine S. Tweden, Michael G. Sarr, Charles J. Billington

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background/Objectives. Vagal block therapy (vBloc) is effective for moderate to severe obesity at one year. Subjects/Methods. The ReCharge trial is a double-blind, randomized controlled clinical trial of 239 participants with body mass index (BMI) of 40 to 45 kg/m or 35 to 40 kg/m with one or more obesity-related conditions. Interventions were implantation of either vBloc or Sham devices and weight management counseling. Mixed models assessed percent excess weight loss (%EWL) and total weight loss (%TWL) in intent-to-treat analyses. At 18 months, 142 (88%) vBloc and 64 (83%) Sham patients remained enrolled in the study. Results. 18-month weight loss was 23% EWL (8.8% TWL) for vBloc and 10% EWL (3.8% TWL) for Sham (P

Original languageEnglish (US)
Article number365604
JournalJournal of Obesity
Volume2015
DOIs
StatePublished - 2015

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Nerve Block
Weight Loss
Morbid Obesity
Therapeutics
Counseling
Body Mass Index
Randomized Controlled Trials
Obesity
Weights and Measures
Equipment and Supplies

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Shikora, S. A., Wolfe, B., Apovian, C. M., Anvari, M., Sarwer, D. B., Gibbons, R. D., ... Billington, C. J. (2015). Sustained Weight Loss with Vagal Nerve Blockade but Not with Sham: 18-Month Results of the ReCharge Trial. Journal of Obesity, 2015, [365604]. https://doi.org/10.1155/2015/365604

Sustained Weight Loss with Vagal Nerve Blockade but Not with Sham : 18-Month Results of the ReCharge Trial. / Shikora, Scott A.; Wolfe, Bruce; Apovian, Caroline M.; Anvari, Mehran; Sarwer, David B.; Gibbons, Robert D.; Ikramuddin, Sayeed; Miller, Christopher J.; Knudson, Mark B.; Tweden, Katherine S.; Sarr, Michael G.; Billington, Charles J.

In: Journal of Obesity, Vol. 2015, 365604, 2015.

Research output: Contribution to journalArticle

Shikora, SA, Wolfe, B, Apovian, CM, Anvari, M, Sarwer, DB, Gibbons, RD, Ikramuddin, S, Miller, CJ, Knudson, MB, Tweden, KS, Sarr, MG & Billington, CJ 2015, 'Sustained Weight Loss with Vagal Nerve Blockade but Not with Sham: 18-Month Results of the ReCharge Trial', Journal of Obesity, vol. 2015, 365604. https://doi.org/10.1155/2015/365604
Shikora, Scott A. ; Wolfe, Bruce ; Apovian, Caroline M. ; Anvari, Mehran ; Sarwer, David B. ; Gibbons, Robert D. ; Ikramuddin, Sayeed ; Miller, Christopher J. ; Knudson, Mark B. ; Tweden, Katherine S. ; Sarr, Michael G. ; Billington, Charles J. / Sustained Weight Loss with Vagal Nerve Blockade but Not with Sham : 18-Month Results of the ReCharge Trial. In: Journal of Obesity. 2015 ; Vol. 2015.
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abstract = "Background/Objectives. Vagal block therapy (vBloc) is effective for moderate to severe obesity at one year. Subjects/Methods. The ReCharge trial is a double-blind, randomized controlled clinical trial of 239 participants with body mass index (BMI) of 40 to 45 kg/m or 35 to 40 kg/m with one or more obesity-related conditions. Interventions were implantation of either vBloc or Sham devices and weight management counseling. Mixed models assessed percent excess weight loss ({\%}EWL) and total weight loss ({\%}TWL) in intent-to-treat analyses. At 18 months, 142 (88{\%}) vBloc and 64 (83{\%}) Sham patients remained enrolled in the study. Results. 18-month weight loss was 23{\%} EWL (8.8{\%} TWL) for vBloc and 10{\%} EWL (3.8{\%} TWL) for Sham (P",
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