Surveillance of transcriptomes in basic military trainees with normal, febrile respiratory illness, and convalescent phenotypes

D. C. Thach, B. K. Agan, C. Olsen, J. Diao, B. Lin, J. Gomez, M. Jesse, M. Jenkins, R. Rowley, E. Hanson, C. Tibbetts, D. A. Stenger, E. Walter, P. Demitry, T. Difato, R. Holliday, R. Kruzelock, L. Daum, D. Metzgar, D. NiemeyerK. Russell, M. Archer, R. Bravo, N. Freed, J. Fuller, K. Gratwick, B. Johnson, E. Lawrence, C. Meador, H. Melgarejo, K. Mueller, D. Pearson, A. Purkayastha, J. Santiago, D. Seto, F. Stotler, J. Thornton, Z. Wang, D. Watson, S. Worthy, G. Vora, Kathleen (Kathy) Grant, C. James

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Gene expression profiles permit analysis of host immune response at the transcriptome level. We used the Pax gene Blood RNA (PAX) System and Affymetrix microarrays (HG-U133A&B) to survey profiles in basic military trainees and to classify them as healthy, febrile respiratory illness (FRI) without adenovirus, FRI with adenovirus, and convalescent from FRI with adenovirus. We assessed quality metrics of RNA processing for microarrays. Class prediction analysis discovered nested sets of transcripts that could categorize the phenotypes with optimized accuracy of 99% (nonfebrile vs febrile, P

Original languageEnglish (US)
Pages (from-to)588-595
Number of pages8
JournalGenes and Immunity
Volume6
Issue number7
DOIs
StatePublished - Oct 2005
Externally publishedYes

Fingerprint

Transcriptome
Fever
Adenoviridae
Phenotype
RNA
Alternative Splicing
Genes

Keywords

  • Infection phenotypes
  • Surveillance
  • Transcriptome

ASJC Scopus subject areas

  • Genetics(clinical)
  • Immunology
  • Genetics

Cite this

Surveillance of transcriptomes in basic military trainees with normal, febrile respiratory illness, and convalescent phenotypes. / Thach, D. C.; Agan, B. K.; Olsen, C.; Diao, J.; Lin, B.; Gomez, J.; Jesse, M.; Jenkins, M.; Rowley, R.; Hanson, E.; Tibbetts, C.; Stenger, D. A.; Walter, E.; Demitry, P.; Difato, T.; Holliday, R.; Kruzelock, R.; Daum, L.; Metzgar, D.; Niemeyer, D.; Russell, K.; Archer, M.; Bravo, R.; Freed, N.; Fuller, J.; Gratwick, K.; Johnson, B.; Lawrence, E.; Meador, C.; Melgarejo, H.; Mueller, K.; Pearson, D.; Purkayastha, A.; Santiago, J.; Seto, D.; Stotler, F.; Thornton, J.; Wang, Z.; Watson, D.; Worthy, S.; Vora, G.; Grant, Kathleen (Kathy); James, C.

In: Genes and Immunity, Vol. 6, No. 7, 10.2005, p. 588-595.

Research output: Contribution to journalArticle

Thach, DC, Agan, BK, Olsen, C, Diao, J, Lin, B, Gomez, J, Jesse, M, Jenkins, M, Rowley, R, Hanson, E, Tibbetts, C, Stenger, DA, Walter, E, Demitry, P, Difato, T, Holliday, R, Kruzelock, R, Daum, L, Metzgar, D, Niemeyer, D, Russell, K, Archer, M, Bravo, R, Freed, N, Fuller, J, Gratwick, K, Johnson, B, Lawrence, E, Meador, C, Melgarejo, H, Mueller, K, Pearson, D, Purkayastha, A, Santiago, J, Seto, D, Stotler, F, Thornton, J, Wang, Z, Watson, D, Worthy, S, Vora, G, Grant, KK & James, C 2005, 'Surveillance of transcriptomes in basic military trainees with normal, febrile respiratory illness, and convalescent phenotypes', Genes and Immunity, vol. 6, no. 7, pp. 588-595. https://doi.org/10.1038/sj.gene.6364244
Thach, D. C. ; Agan, B. K. ; Olsen, C. ; Diao, J. ; Lin, B. ; Gomez, J. ; Jesse, M. ; Jenkins, M. ; Rowley, R. ; Hanson, E. ; Tibbetts, C. ; Stenger, D. A. ; Walter, E. ; Demitry, P. ; Difato, T. ; Holliday, R. ; Kruzelock, R. ; Daum, L. ; Metzgar, D. ; Niemeyer, D. ; Russell, K. ; Archer, M. ; Bravo, R. ; Freed, N. ; Fuller, J. ; Gratwick, K. ; Johnson, B. ; Lawrence, E. ; Meador, C. ; Melgarejo, H. ; Mueller, K. ; Pearson, D. ; Purkayastha, A. ; Santiago, J. ; Seto, D. ; Stotler, F. ; Thornton, J. ; Wang, Z. ; Watson, D. ; Worthy, S. ; Vora, G. ; Grant, Kathleen (Kathy) ; James, C. / Surveillance of transcriptomes in basic military trainees with normal, febrile respiratory illness, and convalescent phenotypes. In: Genes and Immunity. 2005 ; Vol. 6, No. 7. pp. 588-595.
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AU - Diao, J.

AU - Lin, B.

AU - Gomez, J.

AU - Jesse, M.

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AU - Mueller, K.

AU - Pearson, D.

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AU - Santiago, J.

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AU - Stotler, F.

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