Surgery is associated with ventricular enlargement as well as cognitive and functional decline

Katie J. Schenning; Charles F. Murchison; Nora C. Mattek; Lisa C. Silbert; Jeffrey A. Kaye; Joseph F. Quinn

doi:10.1016/j.jalz.2015.10.004

Surgery is associated with ventricular enlargement as well as cognitive and functional decline

Katie J. Schenning, Charles F. Murchison, Nora C. Mattek, Lisa C. Silbert, Jeffrey A. Kaye, Joseph F. Quinn

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38 Scopus citations

Abstract

Introduction In preclinical studies, surgery/anesthesia contribute to cognitive decline and enhance neuropathologic changes underlying Alzheimer's disease (AD). Nevertheless, the link between surgery, anesthesia, apolipoprotein E ϵ4 (APOE ϵ4), and AD remains unclear. Methods We performed a retrospective cohort analysis of two prospective longitudinal aging studies. Mixed-effects statistical models were used to assess the relationship between surgical/anesthetic exposure, the APOE genotype, and rate of change in measures of cognition, function, and brain volumes. Results The surgical group (n = 182) experienced a more rapid rate of deterioration compared with the nonsurgical group (n = 345) in several cognitive, functional, and brain magnetic resonance imaging measures. Furthermore, there was a significant synergistic effect of anesthesia/surgery exposure and presence of the APOE ϵ4 allele in the decline of multiple cognitive and functional measures. Discussion These data provide insight into the role of surgical exposure as a risk factor for cognitive and functional decline in older adults.

Original language	English (US)
Pages (from-to)	590-597
Number of pages	8
Journal	Alzheimer's and Dementia
Volume	12
Issue number	5
DOIs	https://doi.org/10.1016/j.jalz.2015.10.004
State	Published - May 1 2016

Keywords

Alzheimer's disease
Anesthesia
Apolipoprotein E ϵ4
Cognitive decline
Cohort study
Epidemiology
Postoperative
Surgery
Volumetric MRI

ASJC Scopus subject areas

Epidemiology
Health Policy
Developmental Neuroscience
Clinical Neurology
Geriatrics and Gerontology
Psychiatry and Mental health
Cellular and Molecular Neuroscience

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10.1016/j.jalz.2015.10.004

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title = "Surgery is associated with ventricular enlargement as well as cognitive and functional decline",

abstract = "Introduction In preclinical studies, surgery/anesthesia contribute to cognitive decline and enhance neuropathologic changes underlying Alzheimer's disease (AD). Nevertheless, the link between surgery, anesthesia, apolipoprotein E ϵ4 (APOE ϵ4), and AD remains unclear. Methods We performed a retrospective cohort analysis of two prospective longitudinal aging studies. Mixed-effects statistical models were used to assess the relationship between surgical/anesthetic exposure, the APOE genotype, and rate of change in measures of cognition, function, and brain volumes. Results The surgical group (n = 182) experienced a more rapid rate of deterioration compared with the nonsurgical group (n = 345) in several cognitive, functional, and brain magnetic resonance imaging measures. Furthermore, there was a significant synergistic effect of anesthesia/surgery exposure and presence of the APOE ϵ4 allele in the decline of multiple cognitive and functional measures. Discussion These data provide insight into the role of surgical exposure as a risk factor for cognitive and functional decline in older adults.",

keywords = "Alzheimer's disease, Anesthesia, Apolipoprotein E ϵ4, Cognitive decline, Cohort study, Epidemiology, Postoperative, Surgery, Volumetric MRI",

author = "Schenning, {Katie J.} and Murchison, {Charles F.} and Mattek, {Nora C.} and Silbert, {Lisa C.} and Kaye, {Jeffrey A.} and Quinn, {Joseph F.}",

note = "Funding Information: This study was funded in part by an Agency for Healthcare Research and Quality-funded BIRCWH K12 award (K12 HD 043488) and by grants from the National Institutes of Health ( P30AG024978 , R01AG024059 , P30AG008017 , 1U10NS077350-01 , R01AG036772 , and R01AG043398 ) and a Merit Review Grant from the U.S. Department of Veterans Affairs . The authors thank Kirk Hogan, for reviewing drafts of the article. Publisher Copyright: {\textcopyright} 2016 Alzheimer's Association. Published by Elsevier Inc. All rights reserved.",

year = "2016",

month = may,

day = "1",

doi = "10.1016/j.jalz.2015.10.004",

language = "English (US)",

volume = "12",

pages = "590--597",

journal = "Alzheimer's and Dementia",

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T1 - Surgery is associated with ventricular enlargement as well as cognitive and functional decline

AU - Schenning, Katie J.

AU - Murchison, Charles F.

AU - Mattek, Nora C.

AU - Silbert, Lisa C.

AU - Kaye, Jeffrey A.

AU - Quinn, Joseph F.

N1 - Funding Information: This study was funded in part by an Agency for Healthcare Research and Quality-funded BIRCWH K12 award (K12 HD 043488) and by grants from the National Institutes of Health ( P30AG024978 , R01AG024059 , P30AG008017 , 1U10NS077350-01 , R01AG036772 , and R01AG043398 ) and a Merit Review Grant from the U.S. Department of Veterans Affairs . The authors thank Kirk Hogan, for reviewing drafts of the article. Publisher Copyright: © 2016 Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Introduction In preclinical studies, surgery/anesthesia contribute to cognitive decline and enhance neuropathologic changes underlying Alzheimer's disease (AD). Nevertheless, the link between surgery, anesthesia, apolipoprotein E ϵ4 (APOE ϵ4), and AD remains unclear. Methods We performed a retrospective cohort analysis of two prospective longitudinal aging studies. Mixed-effects statistical models were used to assess the relationship between surgical/anesthetic exposure, the APOE genotype, and rate of change in measures of cognition, function, and brain volumes. Results The surgical group (n = 182) experienced a more rapid rate of deterioration compared with the nonsurgical group (n = 345) in several cognitive, functional, and brain magnetic resonance imaging measures. Furthermore, there was a significant synergistic effect of anesthesia/surgery exposure and presence of the APOE ϵ4 allele in the decline of multiple cognitive and functional measures. Discussion These data provide insight into the role of surgical exposure as a risk factor for cognitive and functional decline in older adults.

AB - Introduction In preclinical studies, surgery/anesthesia contribute to cognitive decline and enhance neuropathologic changes underlying Alzheimer's disease (AD). Nevertheless, the link between surgery, anesthesia, apolipoprotein E ϵ4 (APOE ϵ4), and AD remains unclear. Methods We performed a retrospective cohort analysis of two prospective longitudinal aging studies. Mixed-effects statistical models were used to assess the relationship between surgical/anesthetic exposure, the APOE genotype, and rate of change in measures of cognition, function, and brain volumes. Results The surgical group (n = 182) experienced a more rapid rate of deterioration compared with the nonsurgical group (n = 345) in several cognitive, functional, and brain magnetic resonance imaging measures. Furthermore, there was a significant synergistic effect of anesthesia/surgery exposure and presence of the APOE ϵ4 allele in the decline of multiple cognitive and functional measures. Discussion These data provide insight into the role of surgical exposure as a risk factor for cognitive and functional decline in older adults.

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KW - Anesthesia

KW - Apolipoprotein E ϵ4

KW - Cognitive decline

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KW - Epidemiology

KW - Postoperative

KW - Surgery

KW - Volumetric MRI

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Surgery is associated with ventricular enlargement as well as cognitive and functional decline

Abstract

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