Abstract
Introduction In preclinical studies, surgery/anesthesia contribute to cognitive decline and enhance neuropathologic changes underlying Alzheimer's disease (AD). Nevertheless, the link between surgery, anesthesia, apolipoprotein E ϵ4 (APOE ϵ4), and AD remains unclear. Methods We performed a retrospective cohort analysis of two prospective longitudinal aging studies. Mixed-effects statistical models were used to assess the relationship between surgical/anesthetic exposure, the APOE genotype, and rate of change in measures of cognition, function, and brain volumes. Results The surgical group (n = 182) experienced a more rapid rate of deterioration compared with the nonsurgical group (n = 345) in several cognitive, functional, and brain magnetic resonance imaging measures. Furthermore, there was a significant synergistic effect of anesthesia/surgery exposure and presence of the APOE ϵ4 allele in the decline of multiple cognitive and functional measures. Discussion These data provide insight into the role of surgical exposure as a risk factor for cognitive and functional decline in older adults.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 590-597 |
| Number of pages | 8 |
| Journal | Alzheimer's and Dementia |
| Volume | 12 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1 2016 |
Keywords
- Alzheimer's disease
- Anesthesia
- Apolipoprotein E ϵ4
- Cognitive decline
- Cohort study
- Epidemiology
- Postoperative
- Surgery
- Volumetric MRI
ASJC Scopus subject areas
- Clinical Neurology
- Geriatrics and Gerontology
- Psychiatry and Mental health
- Cellular and Molecular Neuroscience
- Health Policy
- Developmental Neuroscience
- Epidemiology