Abstract
Two patients with suprasellar germinomas were initially treated successfully with radiotherapy, but subsequently they developed recurrent tumor 2 1/2 and 12 years later. The recurrent tumor was solely extraneural in the first patient because of seeding from a ventriculoperitoneal shunt, and in the second patient the tumor recurred at its initial site as well as in the 4th ventricle. Both tumors secreted the β-subunit of human chorionic gonadotropin. A dramatic tumor response was seen in both patients with systemic chemotherapy consisting of a combination of cis-platinum, bleomycin, and vinblastine. The 'small cells' in one of the suprasellar germinomas were shown to be predominately T lymphocytes on the basis of an examination of the cell surface markers on these cells.
Original language | English (US) |
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Pages (from-to) | 352-358 |
Number of pages | 7 |
Journal | Neurosurgery |
Volume | 7 |
Issue number | 4 |
DOIs | |
State | Published - 1980 |
Externally published | Yes |
ASJC Scopus subject areas
- Surgery
- Clinical Neurology