Suprarenal aortic flow reduction versus angiotensin I infusion in fetal sheep

Debra Anderson, N. D. Binder

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    In the unanaesthetized fetal sheep, long-term suprarenal aortic blood flow reduction will cause upper body arterial blood pressure to increase. To see if the response to this procedure was entirely due to the concomitant increase in plasma renin activity, we gave an angiotensin I infusion of several days to 7 fetal sheep and compared their responses to those of 4 fetal sheep undergoing partial occlusion of the aorta above the renal arteries. Both protocols caused upper body arterial blood pressure to increase to comparable levels. Angiotensin I infusion had no effect upon venous blood pressure while suprarenal aortic blood flow reduction caused a significant increase in various blood pressure as early as 1 day after blood flow reduction. Haematocrits were unchanged in the fetuses with flow restriction but increased in the infused fetuses. We conclude that long-term angiotensin I infusion in the fetus does not mimic the entire complex of responses to suprarenal aortic blood flow reduction.

    Original languageEnglish (US)
    Pages (from-to)317-321
    Number of pages5
    JournalJournal of Developmental Physiology
    Volume11
    Issue number5
    StatePublished - 1989

    Fingerprint

    Angiotensin I
    Sheep
    Fetus
    Arterial Pressure
    Venous Pressure
    Renal Artery
    Hematocrit
    Renin
    Aorta
    Blood Pressure

    ASJC Scopus subject areas

    • Developmental Biology
    • Physiology

    Cite this

    Suprarenal aortic flow reduction versus angiotensin I infusion in fetal sheep. / Anderson, Debra; Binder, N. D.

    In: Journal of Developmental Physiology, Vol. 11, No. 5, 1989, p. 317-321.

    Research output: Contribution to journalArticle

    Anderson, Debra ; Binder, N. D. / Suprarenal aortic flow reduction versus angiotensin I infusion in fetal sheep. In: Journal of Developmental Physiology. 1989 ; Vol. 11, No. 5. pp. 317-321.
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