Suprapontine control of breathing

Shakeeb H. Moosavi, David Paydarfar, Steven A. Shea

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations


The current chapter focuses on the functional importance and neuro-anatomical basis of suprapontine control of breathing in humans, which complements the pharmacological and pathological perspectives covered in other sections of this book. For this purpose, suprapontine influences are divided into three broad categories: (1) volitional control; (2) involuntary influences associated with emotions and psychological dis-turbances, and (3) tonic drives including excitatory drives associated with wakefulness. Recent reviews in suprapontine respiratory control focus primarily on functional aspects [1-3], or primarily on the underlying neural substrate [4-6]. This chapter updates these reviews with particular regard to recent studies in humans. We focus more on the second category (involuntary influences), as this has never been reviewed extensively. We have also highlighted two key issues that continue to guide research in the field: (1) interaction between suprapontine-and brainstem-based mechanisms that influence respiratory pump activity, and (2) capacity for learning and adaptation in respiratory control.

Original languageEnglish (US)
Title of host publicationPharmacology and Pathophysiology of the Control of Breathing
PublisherCRC Press
Number of pages32
ISBN (Electronic)9780849359538
ISBN (Print)9780824758905
StatePublished - Jan 1 2005
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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