Suppressor scanning at positions 177 and 236 in the Escherichia coli lactose/H+ cotransporter and stereotypical effects of acidic substituents that suggest a favored orientation of transmembrane segments relative to the lipid bilayer

S. C. King, S. Li

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Acidic substituents for Ala-177 (helix 6) or Tyr-236 (helix 7) in LacY cause effects on sugar recognition and cosubstrate coupling that are stereotypical of neutral substituents. Thus, helices 6 and 7 are probably oriented to produce little side-chain contact with the low dielectric lipid bilayer at positions 177 and 236.

Original languageEnglish (US)
Pages (from-to)2756-2758
Number of pages3
JournalJournal of bacteriology
Volume180
Issue number10
DOIs
StatePublished - 1998

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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