Suppression of simian immunodeficiency virus replication by human immunodeficiency virus type 1 trans-dominant negative rev mutants

C. L. Endres, E. P. Bergquam, Michael Axthelm, Scott Wong

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We demonstrate that trans-dominant negative rev mutants are able to suppress simian immunodeficiency virus provirus replication in both transient cotransfection assays and stably transduced HUT 78 cells. These studies suggest that the efficacy of trans-dominant rev strategies in reducing viral burden may be evaluated in a simian immunodeficiency virus-rhesus macaque animal model.

Original languageEnglish (US)
Pages (from-to)5164-5166
Number of pages3
JournalJournal of Virology
Volume69
Issue number8
StatePublished - 1995

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Simian immunodeficiency virus
Simian Immunodeficiency Virus
Virus Replication
virus replication
Human immunodeficiency virus 1
HIV-1
proviruses
Proviruses
mutants
viral load
Macaca mulatta
Viral Load
Animal Models
animal models
assays
cells

ASJC Scopus subject areas

  • Immunology

Cite this

Suppression of simian immunodeficiency virus replication by human immunodeficiency virus type 1 trans-dominant negative rev mutants. / Endres, C. L.; Bergquam, E. P.; Axthelm, Michael; Wong, Scott.

In: Journal of Virology, Vol. 69, No. 8, 1995, p. 5164-5166.

Research output: Contribution to journalArticle

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