TY - JOUR
T1 - Suppression of longitudinal increase in CSF F2-isoprostanes in Alzkeimer's disease
AU - Quinn, Joseph F.
AU - Montine, Kathleen S.
AU - Moore, Milar
AU - Morrow, Jason D.
AU - Kaye, Jeffrey A.
AU - Montine, Thomas J.
PY - 2004/2
Y1 - 2004/2
N2 - We report the first longitudinal analysis of cerebrospinal fluid (CSF) F2-isoprostanes (IsoPs), quantitative in vivo biomarkers of lipid peroxidation, in patients with mild Alzheimer's disease (AD). CSF F 2-IsoPs (i) were significantly increased in patients followed over one year, (ii) correlated with some clinical indices of dementia following correction for variation in ventricular enlargement, and (iii) were significantly lower in patients who used both a-tocopherol and vitamin C.
AB - We report the first longitudinal analysis of cerebrospinal fluid (CSF) F2-isoprostanes (IsoPs), quantitative in vivo biomarkers of lipid peroxidation, in patients with mild Alzheimer's disease (AD). CSF F 2-IsoPs (i) were significantly increased in patients followed over one year, (ii) correlated with some clinical indices of dementia following correction for variation in ventricular enlargement, and (iii) were significantly lower in patients who used both a-tocopherol and vitamin C.
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U2 - 10.3233/JAD-2004-6110
DO - 10.3233/JAD-2004-6110
M3 - Article
C2 - 15004331
AN - SCOPUS:1842584884
SN - 1387-2877
VL - 6
SP - 93
EP - 97
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
IS - 1
ER -