Suppression of longitudinal increase in CSF F2-isoprostanes in Alzkeimer's disease

Joseph F. Quinn, Kathleen S. Montine, Milar Moore, Jason D. Morrow, Jeffrey A. Kaye, Thomas J. Montine

Research output: Contribution to journalArticlepeer-review

75 Scopus citations


We report the first longitudinal analysis of cerebrospinal fluid (CSF) F2-isoprostanes (IsoPs), quantitative in vivo biomarkers of lipid peroxidation, in patients with mild Alzheimer's disease (AD). CSF F 2-IsoPs (i) were significantly increased in patients followed over one year, (ii) correlated with some clinical indices of dementia following correction for variation in ventricular enlargement, and (iii) were significantly lower in patients who used both a-tocopherol and vitamin C.

Original languageEnglish (US)
Pages (from-to)93-97
Number of pages5
JournalJournal of Alzheimer's Disease
Issue number1
StatePublished - Feb 2004

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


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