Suppression of longitudinal increase in CSF F2-isoprostanes in Alzkeimer's disease

Joseph Quinn, Kathleen S. Montine, Milar Moore, Jason D. Morrow, Jeffrey Kaye, Thomas J. Montine

Research output: Contribution to journalArticle

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Abstract

We report the first longitudinal analysis of cerebrospinal fluid (CSF) F2-isoprostanes (IsoPs), quantitative in vivo biomarkers of lipid peroxidation, in patients with mild Alzheimer's disease (AD). CSF F 2-IsoPs (i) were significantly increased in patients followed over one year, (ii) correlated with some clinical indices of dementia following correction for variation in ventricular enlargement, and (iii) were significantly lower in patients who used both a-tocopherol and vitamin C.

Original languageEnglish (US)
Pages (from-to)93-97
Number of pages5
JournalJournal of Alzheimer's Disease
Volume6
Issue number1
StatePublished - Feb 2004

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F2-Isoprostanes
Cerebrospinal Fluid
Isoprostanes
Tocopherols
Lipid Peroxidation
Ascorbic Acid
Dementia
Alzheimer Disease
Biomarkers

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology

Cite this

Suppression of longitudinal increase in CSF F2-isoprostanes in Alzkeimer's disease. / Quinn, Joseph; Montine, Kathleen S.; Moore, Milar; Morrow, Jason D.; Kaye, Jeffrey; Montine, Thomas J.

In: Journal of Alzheimer's Disease, Vol. 6, No. 1, 02.2004, p. 93-97.

Research output: Contribution to journalArticle

Quinn, J, Montine, KS, Moore, M, Morrow, JD, Kaye, J & Montine, TJ 2004, 'Suppression of longitudinal increase in CSF F2-isoprostanes in Alzkeimer's disease', Journal of Alzheimer's Disease, vol. 6, no. 1, pp. 93-97.
Quinn, Joseph ; Montine, Kathleen S. ; Moore, Milar ; Morrow, Jason D. ; Kaye, Jeffrey ; Montine, Thomas J. / Suppression of longitudinal increase in CSF F2-isoprostanes in Alzkeimer's disease. In: Journal of Alzheimer's Disease. 2004 ; Vol. 6, No. 1. pp. 93-97.
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