Suppression of granulopoiesis by T-lymphocytes in two patients with disseminated mycobacterial infection

G. C. Bagby, D. N. Gilbert

    Research output: Contribution to journalArticle

    13 Scopus citations

    Abstract

    Two patients with disseminated mycobacterial infection presented with severe neutropenia and hematopoietic failure. Marrow cells were obtained from each patient and were cultured in methylcellulose before and after the removal of mononuclear phagocytes, T-lymphocytes, or both from the marrow cell suspension. Glucocorticosteroid-resistant T-lymphocytes markedly inhibited granulopoiesis, but mononuclear phagocytes did not. Indomethacin inhibition of prostaglandin synthesis did not influence suppression of colony growth by the inhibitory lymphocytes. In the one patient who responded favorably to antituberculous therapy, the in-vitro T-lymphocyte inhibition of granulopoiesis disappeared as the neutropenia resolved. Thus, in some patients with disseminated mycobacterial infection, clinical bone marrow failure may be mediated, at least partly, by T-lymphocytes that suppress hematopoiesis.

    Original languageEnglish (US)
    Pages (from-to)478-481
    Number of pages4
    JournalAnnals of internal medicine
    Volume94
    Issue number4 I
    DOIs
    StatePublished - Jan 1 1981

    ASJC Scopus subject areas

    • Internal Medicine

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