Suppression of granulopoiesis by T-lymphocytes in two patients with disseminated mycobacterial infection

G. C. Bagby, D. N. Gilbert

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Two patients with disseminated mycobacterial infection presented with severe neutropenia and hematopoietic failure. Marrow cells were obtained from each patient and were cultured in methylcellulose before and after the removal of mononuclear phagocytes, T-lymphocytes, or both from the marrow cell suspension. Glucocorticosteroid-resistant T-lymphocytes markedly inhibited granulopoiesis, but mononuclear phagocytes did not. Indomethacin inhibition of prostaglandin synthesis did not influence suppression of colony growth by the inhibitory lymphocytes. In the one patient who responded favorably to antituberculous therapy, the in-vitro T-lymphocyte inhibition of granulopoiesis disappeared as the neutropenia resolved. Thus, in some patients with disseminated mycobacterial infection, clinical bone marrow failure may be mediated, at least partly, by T-lymphocytes that suppress hematopoiesis.

Original languageEnglish (US)
Pages (from-to)478-481
Number of pages4
JournalAnnals of internal medicine
Volume94
Issue number4 I
DOIs
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • Internal Medicine

Fingerprint

Dive into the research topics of 'Suppression of granulopoiesis by T-lymphocytes in two patients with disseminated mycobacterial infection'. Together they form a unique fingerprint.

Cite this