Supersensitivity to light

Possible trait marker for manic-depressive illness

Alfred Lewy, J. I. Nurnberger, T. A. Wehr, D. Pack, L. E. Becker, R. L. Powell, D. A. Newsome

Research output: Contribution to journalArticle

208 Citations (Scopus)

Abstract

Exposure to light during the night reduces plasma melatonin levels. A previous study showed that, in response to light, nighttime plasma melatonin levels fell twice as much in a group of acutely ill manic-depressive patients as in a group of normal subjects. The present study compares 11 euthymic manic-depressive patients not taking medications with 24 age- and sex-matched normal subjects. Melatonin levels in these patients also fell twice as much as the levels of the normal subjects, suggesting that supersensitivity to light may be a trait marker for bipolar affective disorder.

Original languageEnglish (US)
Pages (from-to)725-727
Number of pages3
JournalAmerican Journal of Psychiatry
Volume142
Issue number6
StatePublished - 1985

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Melatonin
Light
Mood Disorders
Bipolar Disorder
Major Affective Disorder 2

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Lewy, A., Nurnberger, J. I., Wehr, T. A., Pack, D., Becker, L. E., Powell, R. L., & Newsome, D. A. (1985). Supersensitivity to light: Possible trait marker for manic-depressive illness. American Journal of Psychiatry, 142(6), 725-727.

Supersensitivity to light : Possible trait marker for manic-depressive illness. / Lewy, Alfred; Nurnberger, J. I.; Wehr, T. A.; Pack, D.; Becker, L. E.; Powell, R. L.; Newsome, D. A.

In: American Journal of Psychiatry, Vol. 142, No. 6, 1985, p. 725-727.

Research output: Contribution to journalArticle

Lewy, A, Nurnberger, JI, Wehr, TA, Pack, D, Becker, LE, Powell, RL & Newsome, DA 1985, 'Supersensitivity to light: Possible trait marker for manic-depressive illness', American Journal of Psychiatry, vol. 142, no. 6, pp. 725-727.
Lewy A, Nurnberger JI, Wehr TA, Pack D, Becker LE, Powell RL et al. Supersensitivity to light: Possible trait marker for manic-depressive illness. American Journal of Psychiatry. 1985;142(6):725-727.
Lewy, Alfred ; Nurnberger, J. I. ; Wehr, T. A. ; Pack, D. ; Becker, L. E. ; Powell, R. L. ; Newsome, D. A. / Supersensitivity to light : Possible trait marker for manic-depressive illness. In: American Journal of Psychiatry. 1985 ; Vol. 142, No. 6. pp. 725-727.
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