Superparamagnetic iron oxide nanoparticles: Diagnostic magnetic resonance imaging and potential therapeutic applications in neurooncology and central nervous system inflammatory pathologies, a review

Jason S. Weinstein, Csanad G. Varallyay, Edit Dosa, Seymur Gahramanov, Bronwyn Hamilton, William Rooney, Leslie Muldoon, Edward Neuwelt

Research output: Contribution to journalArticle

328 Citations (Scopus)

Abstract

Superparamagnetic iron oxide nanoparticles have diverse diagnostic and potential therapeutic applications in the central nervous system (CNS). They are useful as magnetic resonance imaging (MRI) contrast agents to evaluate: areas of blood-brain barrier (BBB) dysfunction related to tumors and other neuroinflammatory pathologies, the cerebrovasculature using perfusion-weighted MRI sequences, and in vivo cellular tracking in CNS disease or injury. Novel, targeted, nanoparticle synthesis strategies will allow for a rapidly expanding range of applications in patients with brain tumors, cerebral ischemia or stroke, carotid atherosclerosis, multiple sclerosis, traumatic brain injury, and epilepsy. These strategies may ultimately improve disease detection, therapeutic monitoring, and treatment efficacy especially in the context of antiangiogenic chemotherapy and antiinflammatory medications. The purpose of this review is to outline the current status of superparamagnetic iron oxide nanoparticles in the context of biomedical nanotechnology as they apply to diagnostic MRI and potential therapeutic applications in neurooncology and other CNS inflammatory conditions.

Original languageEnglish (US)
Pages (from-to)15-35
Number of pages21
JournalJournal of Cerebral Blood Flow and Metabolism
Volume30
Issue number1
DOIs
StatePublished - Jan 2010

Fingerprint

Nanoparticles
Central Nervous System
Magnetic Resonance Imaging
Pathology
Nervous System Trauma
Nanotechnology
Carotid Artery Diseases
Magnetic Resonance Angiography
Central Nervous System Diseases
Brain Ischemia
Blood-Brain Barrier
Brain Neoplasms
Contrast Media
Multiple Sclerosis
Epilepsy
Anti-Inflammatory Agents
Therapeutics
Stroke
Drug Therapy
ferric oxide

Keywords

  • Blood-brain barrier
  • CNS tumors
  • Magnetic resonance imaging
  • Ultrasmall superparamagnetic iron oxide nanoparticles

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Neurology

Cite this

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AU - Rooney, William

AU - Muldoon, Leslie

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