28Silicon Irradiation Impairs Contextual Fear Memory in B6D2F1 Mice

Jacob Raber, Tessa Marzulla, Blair Stewart, Amy Kronenberg, Mitchell Turker

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The space radiation environment consists of multiple species of charged particles, including 28Si, 48Ti and protons that may impact cognition, but their damaging effects have been poorly defined. In mouse studies, C57Bl6/J homozygous wild-type mice and genetic mutant mice on a C57Bl6/J background have typically been used for assessing effects of space radiation on cognition. In contrast, little is known about the radiation response of mice on a heterozygous background. Therefore, in the current study we tested the effects of 28Si, 48Ti and proton radiation on hippocampus-dependent contextual fear memory and hippocampus-independent cued fear memory in C57Bl6/J × DBA2/J F1 (B6D2F1) mice three months after irradiation. Contextual fear memory was impaired at a 1.6 Gy dose of 28Si radiation, but not cued fear memory. 48Ti or proton irradiation did not affect either type of memory. Based on earlier space radiation cognitive data in C57Bl6/J mice, these data highlight the importance of including different genetic backgrounds in studies aimed at assessing cognitive changes after exposure to space radiation.

Original languageEnglish (US)
Pages (from-to)708-712
Number of pages5
JournalRadiation Research
Volume183
Issue number6
DOIs
StatePublished - Jun 1 2015

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fear
Fear
mice
extraterrestrial radiation
Radiation
irradiation
hippocampus
cognition
Protons
Cognition
Hippocampus
radiation
proton irradiation
protons
Radiation Effects
charged particles
dosage

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Biophysics
  • Radiation

Cite this

28Silicon Irradiation Impairs Contextual Fear Memory in B6D2F1 Mice. / Raber, Jacob; Marzulla, Tessa; Stewart, Blair; Kronenberg, Amy; Turker, Mitchell.

In: Radiation Research, Vol. 183, No. 6, 01.06.2015, p. 708-712.

Research output: Contribution to journalArticle

Raber, Jacob ; Marzulla, Tessa ; Stewart, Blair ; Kronenberg, Amy ; Turker, Mitchell. / 28Silicon Irradiation Impairs Contextual Fear Memory in B6D2F1 Mice. In: Radiation Research. 2015 ; Vol. 183, No. 6. pp. 708-712.
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