1H-magnetic resonance spectroscopy markers of cognitive and language ability in clinical subtypes of autism spectrum disorders

Lidia Gabis, Huang Wei, Allen Azizian, Carla DeVincent, Alina Tudorica, Yael Kesner-Baruch, Patricia Roche, John Pomeroy

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

This study assessed metabolic functioning of regional brain areas to address whether there is a neurometabolic profile reflecting the underlying neuropathology in individuals with autism spectrum disorders, and if varied profiles correlate with the clinical subtypes. Thirteen children (7-16 years) with autism spectrum disorders and 8 typically developing children were compared on 1H-magnetic resonance spectroscopy data collected from hippocampus-amygdala and cerebellar regions. The autism spectrum disorder group had significantly lower N-acetyl-aspartate/creatine ratios bilaterally in the hippocampus-amygdala but not cerebellum, whereas myo-inositol/creatine was significantly increased in all measured regions. Choline/creatine was also significantly elevated in the left hippocampus-amygdala and cerebellar regions of children with autism spectrum disorder. Comparisons within the autism spectrum disorder group when clinically subdivided by history of speech delay revealed significant metabolic ratio differences. Magnetic resonance spectroscopy can provide important information regarding abnormal brain metabolism and clinical classification in autism spectrum disorders.

Original languageEnglish (US)
Pages (from-to)766-774
Number of pages9
JournalJournal of child neurology
Volume23
Issue number7
DOIs
StatePublished - Jul 2008
Externally publishedYes

Keywords

  • 1H-magnetic resonance spectroscopy
  • Autism spectrum disorders
  • Brain imaging
  • Language

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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