18F-sodium fluoride PET/CT in oncology: An atlas of SUVs

Nathanael Sabbah, Tatianie Jackson, Camila Mosci, Mehran Jamali, Ryogo Minamimoto, Andrew Quon, Erik S. Mittra, Andrei Iagaru

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22 Scopus citations


Purpose: The purpose of this study was to analyze the distribution of 18F Sodium Fluoride (18F-NaF) uptake in the normal skeleton, benign and malignant bone lesions, and extraskeletal tissues, using semiquantitative SUV measurements. Patients andMethods: We retrospectively analyzed data from 129 patients who had 18F-NaF PET/CT at our institution for an oncological diagnosis between 2007 and 2014. There were 99 men and 30 women, 19 to 90 years old (mean [SD], 61.5 [15.5]). The range, average, and SD of SUV were measured for normal bone and extraskeletal tissues uptake for the entire patient population. A separate statistical analysis was performed to compare group A, which corresponds to the population of patient with no 18F-NaF-avid metastatic lesions, and group B, which corresponds to the population of patient with 18F-NaF-avid metastatic lesions. We also measured SUVmax and SUVmean for bony metastases and degenerative changes Results: The PET/CT images were acquired at 30 to 169 minutes (mean [SD], 76.5 [22.8]) after injection of 3.9 to 13.6 mCi (mean [SD], 7.3 [2.4]) of 18F-NaF. The range and mean (SD) of SUVmax for 18F-NaF-avid metastasis were 4.5 to 103.3 and 25.9 (16.6) and for 18F-NaF-avid degenerative changes were 3.3 to 52.1 and 16.5 (7.9), respectively. Conclusions: Various skeletal sites have different normal SUVs. Skeletal metastases have different SUVs when compared with benign findings such as degenerative changes.

Original languageEnglish (US)
Pages (from-to)e228-e231
JournalClinical Nuclear Medicine
Issue number4
StatePublished - Apr 21 2015


  • Atlas
  • F-NaF
  • PET/CT
  • SUV

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Sabbah, N., Jackson, T., Mosci, C., Jamali, M., Minamimoto, R., Quon, A., Mittra, E. S., & Iagaru, A. (2015). 18F-sodium fluoride PET/CT in oncology: An atlas of SUVs. Clinical Nuclear Medicine, 40(4), e228-e231. https://doi.org/10.1097/RLU.0000000000000633