[18F]-2-fluoro-2-deoxyglucose transport kinetics as a function of extracellular glucose concentration in malignant glioma, fibroblast and macrophage cells in vitro

Robert C. Burrows, Scott D. Freeman, Aaron W. Charlop, Robert W. Wiseman, Tom C.H. Adamsen, Kenneth A. Krohn, Alexander M. Spence

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

FDG-PET is used to measure the metabolic rate of glucose. Transport and phosphorylation determine the amount of hexose analog that is phosphorylated and trapped. Competition occurs for both events, such that extracellular glucose concentration affects the FDG image. This study investigated the effect of glucose concentration on the rate of FDG accumulation in three cell lines. The results show that extracellular glucose concentration has a greater impact on the rate of FDG accumulation than the relative abundance of GLUT transporter subtypes.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalNuclear Medicine and Biology
Volume31
Issue number1
DOIs
StatePublished - Jan 2004

Keywords

  • GLUT isoforms
  • Glioma
  • Hexose metabolism
  • Hexose transport
  • Lumped Constant
  • Positron Emission Tomography

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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