16                         Oxygen irradiation enhances cued fear memory in B6D2F1 mice

Jacob Raber; Tessa Marzulla; Amy Kronenberg; Mitchell S. Turker

doi:10.1016/j.lssr.2015.10.004

¹⁶ Oxygen irradiation enhances cued fear memory in B6D2F1 mice

Jacob Raber, Tessa Marzulla, Amy Kronenberg, Mitchell S. Turker

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

The space radiation environment includes energetic charged particles that may impact cognitive performance. We assessed the effects of ¹⁶ O ion irradiation on cognitive performance of C57BL/6J × DBA/2J F1 (B6D2F1) mice at OHSU (Portland, OR) one month following irradiation at Brookhaven National Laboratory (BNL, Upton, NY). Hippocampus-dependent contextual fear memory and hippocampus-independent cued fear memory of B6D2F1 mice were tested. ¹⁶ O ion exposure enhanced cued fear memory. This effect showed a bell-shaped dose response curve. Cued fear memory was significantly stronger in mice irradiated with ¹⁶ O ions at a dose of 0.4 or 0.8 Gy than in sham-irradiated mice or following irradiation at 1.6 Gy. In contrast to cued fear memory, contextual fear memory was not affected following ¹⁶ O ion irradiation at the doses used in this study. These data indicate that the amygdala might be particularly susceptible to effects of ¹⁶ O ion exposure.

Original language	English (US)
Pages (from-to)	61-65
Number of pages	5
Journal	Life Sciences in Space Research
Volume	7
DOIs	https://doi.org/10.1016/j.lssr.2015.10.004
State	Published - Nov 2015

Keywords

Amygdala
Contextual
Cued
Fear memory
Hippocampus
Irradiation

ASJC Scopus subject areas

Radiation
Ecology
Astronomy and Astrophysics
Agricultural and Biological Sciences (miscellaneous)
Health, Toxicology and Mutagenesis

Access to Document

10.1016/j.lssr.2015.10.004

Cite this

@article{4748813e74264b418a89198453b9e6f0,

title = "16 Oxygen irradiation enhances cued fear memory in B6D2F1 mice ",

abstract = " The space radiation environment includes energetic charged particles that may impact cognitive performance. We assessed the effects of 16 O ion irradiation on cognitive performance of C57BL/6J × DBA/2J F1 (B6D2F1) mice at OHSU (Portland, OR) one month following irradiation at Brookhaven National Laboratory (BNL, Upton, NY). Hippocampus-dependent contextual fear memory and hippocampus-independent cued fear memory of B6D2F1 mice were tested. 16 O ion exposure enhanced cued fear memory. This effect showed a bell-shaped dose response curve. Cued fear memory was significantly stronger in mice irradiated with 16 O ions at a dose of 0.4 or 0.8 Gy than in sham-irradiated mice or following irradiation at 1.6 Gy. In contrast to cued fear memory, contextual fear memory was not affected following 16 O ion irradiation at the doses used in this study. These data indicate that the amygdala might be particularly susceptible to effects of 16 O ion exposure.",

keywords = "Amygdala, Contextual, Cued, Fear memory, Hippocampus, Irradiation",

author = "Jacob Raber and Tessa Marzulla and Amy Kronenberg and Turker, {Mitchell S.}",

year = "2015",

month = nov,

doi = "10.1016/j.lssr.2015.10.004",

language = "English (US)",

volume = "7",

pages = "61--65",

journal = "Life Sciences in Space Research",

issn = "2214-5524",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - 16 Oxygen irradiation enhances cued fear memory in B6D2F1 mice

AU - Raber, Jacob

AU - Marzulla, Tessa

AU - Kronenberg, Amy

AU - Turker, Mitchell S.

PY - 2015/11

Y1 - 2015/11

N2 - The space radiation environment includes energetic charged particles that may impact cognitive performance. We assessed the effects of 16 O ion irradiation on cognitive performance of C57BL/6J × DBA/2J F1 (B6D2F1) mice at OHSU (Portland, OR) one month following irradiation at Brookhaven National Laboratory (BNL, Upton, NY). Hippocampus-dependent contextual fear memory and hippocampus-independent cued fear memory of B6D2F1 mice were tested. 16 O ion exposure enhanced cued fear memory. This effect showed a bell-shaped dose response curve. Cued fear memory was significantly stronger in mice irradiated with 16 O ions at a dose of 0.4 or 0.8 Gy than in sham-irradiated mice or following irradiation at 1.6 Gy. In contrast to cued fear memory, contextual fear memory was not affected following 16 O ion irradiation at the doses used in this study. These data indicate that the amygdala might be particularly susceptible to effects of 16 O ion exposure.

AB - The space radiation environment includes energetic charged particles that may impact cognitive performance. We assessed the effects of 16 O ion irradiation on cognitive performance of C57BL/6J × DBA/2J F1 (B6D2F1) mice at OHSU (Portland, OR) one month following irradiation at Brookhaven National Laboratory (BNL, Upton, NY). Hippocampus-dependent contextual fear memory and hippocampus-independent cued fear memory of B6D2F1 mice were tested. 16 O ion exposure enhanced cued fear memory. This effect showed a bell-shaped dose response curve. Cued fear memory was significantly stronger in mice irradiated with 16 O ions at a dose of 0.4 or 0.8 Gy than in sham-irradiated mice or following irradiation at 1.6 Gy. In contrast to cued fear memory, contextual fear memory was not affected following 16 O ion irradiation at the doses used in this study. These data indicate that the amygdala might be particularly susceptible to effects of 16 O ion exposure.

KW - Amygdala

KW - Contextual

KW - Cued

KW - Fear memory

KW - Hippocampus

KW - Irradiation

UR - http://www.scopus.com/inward/record.url?scp=84946547360&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84946547360&partnerID=8YFLogxK

U2 - 10.1016/j.lssr.2015.10.004

DO - 10.1016/j.lssr.2015.10.004

M3 - Article

C2 - 26553639

AN - SCOPUS:84946547360

SN - 2214-5524

VL - 7

SP - 61

EP - 65

JO - Life Sciences in Space Research

JF - Life Sciences in Space Research

ER -