16Oxygen irradiation enhances cued fear memory in B6D2F1 mice

Jacob Raber, Tessa Marzulla, Amy Kronenberg, Mitchell Turker

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The space radiation environment includes energetic charged particles that may impact cognitive performance. We assessed the effects of 16O ion irradiation on cognitive performance of C57BL/6J × DBA/2J F1 (B6D2F1) mice at OHSU (Portland, OR) one month following irradiation at Brookhaven National Laboratory (BNL, Upton, NY). Hippocampus-dependent contextual fear memory and hippocampus-independent cued fear memory of B6D2F1 mice were tested. 16O ion exposure enhanced cued fear memory. This effect showed a bell-shaped dose response curve. Cued fear memory was significantly stronger in mice irradiated with 16O ions at a dose of 0.4 or 0.8 Gy than in sham-irradiated mice or following irradiation at 1.6 Gy. In contrast to cued fear memory, contextual fear memory was not affected following 16O ion irradiation at the doses used in this study. These data indicate that the amygdala might be particularly susceptible to effects of 16O ion exposure.

Original languageEnglish (US)
Pages (from-to)61-65
Number of pages5
JournalLife Sciences in Space Research
Volume7
DOIs
StatePublished - Nov 1 2015

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fear
Fear
mice
irradiation
Ions
ion
hippocampus
ion irradiation
dosage
Hippocampus
extraterrestrial radiation
ions
energetic particles
Amygdala
bells
charged particles
energetics
Radiation
curves
dose

Keywords

  • Amygdala
  • Contextual
  • Cued
  • Fear memory
  • Hippocampus
  • Irradiation

ASJC Scopus subject areas

  • Astronomy and Astrophysics
  • Radiation
  • Health, Toxicology and Mutagenesis
  • Ecology

Cite this

16Oxygen irradiation enhances cued fear memory in B6D2F1 mice. / Raber, Jacob; Marzulla, Tessa; Kronenberg, Amy; Turker, Mitchell.

In: Life Sciences in Space Research, Vol. 7, 01.11.2015, p. 61-65.

Research output: Contribution to journalArticle

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