Sultam thioureas: Synthesis and antiviral activity against west nile virus

Rachel M. Feeny; Diane N. Le; Joseph W. Parks; Mark G. Epstein; Joseph V. Pagano; Albert C. Abbene; Elaina B. Graham; Joanna R. Farrell; Jason R. McGuire; Robert W. Zoellner; Edward J. Valente; Eric Barklis; Warren J.L. Wood

doi:10.1055/s-0031-1290124

Sultam thioureas: Synthesis and antiviral activity against west nile virus

Rachel M. Feeny, Diane N. Le, Joseph W. Parks, Mark G. Epstein, Joseph V. Pagano, Albert C. Abbene, Elaina B. Graham, Joanna R. Farrell, Jason R. McGuire, Robert W. Zoellner, Edward J. Valente, Eric Barklis, Warren J.L. Wood

Molecular Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The syntheses of eleven sultam thioureas, including nine new compounds, are described. These compounds were synthesized from thioureas and include the first sultam thioureas in which the two thiourea nitrogen groups are not identical. In addition, the first X-ray crystal structures of sultam thioureas and the antiviral activity of these compounds against West Nile virus (WNV) are reported.

Original language	English (US)
Pages (from-to)	301-305
Number of pages	5
Journal	Synlett
Issue number	2
DOIs	https://doi.org/10.1055/s-0031-1290124
State	Published - 2012

Keywords

West Nile virus
antiviral agents
heterocycles
medicinal chemistry
sultam thioureas
thioureas

ASJC Scopus subject areas

Organic Chemistry

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10.1055/s-0031-1290124

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title = "Sultam thioureas: Synthesis and antiviral activity against west nile virus",

abstract = "The syntheses of eleven sultam thioureas, including nine new compounds, are described. These compounds were synthesized from thioureas and include the first sultam thioureas in which the two thiourea nitrogen groups are not identical. In addition, the first X-ray crystal structures of sultam thioureas and the antiviral activity of these compounds against West Nile virus (WNV) are reported.",

keywords = "West Nile virus, antiviral agents, heterocycles, medicinal chemistry, sultam thioureas, thioureas",

author = "Feeny, {Rachel M.} and Le, {Diane N.} and Parks, {Joseph W.} and Epstein, {Mark G.} and Pagano, {Joseph V.} and Abbene, {Albert C.} and Graham, {Elaina B.} and Farrell, {Joanna R.} and McGuire, {Jason R.} and Zoellner, {Robert W.} and Valente, {Edward J.} and Eric Barklis and Wood, {Warren J.L.}",

year = "2012",

doi = "10.1055/s-0031-1290124",

language = "English (US)",

pages = "301--305",

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publisher = "Georg Thieme Verlag",

number = "2",

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TY - JOUR

T1 - Sultam thioureas

T2 - Synthesis and antiviral activity against west nile virus

AU - Feeny, Rachel M.

AU - Le, Diane N.

AU - Parks, Joseph W.

AU - Epstein, Mark G.

AU - Pagano, Joseph V.

AU - Abbene, Albert C.

AU - Graham, Elaina B.

AU - Farrell, Joanna R.

AU - McGuire, Jason R.

AU - Zoellner, Robert W.

AU - Valente, Edward J.

AU - Barklis, Eric

AU - Wood, Warren J.L.

PY - 2012

Y1 - 2012

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AB - The syntheses of eleven sultam thioureas, including nine new compounds, are described. These compounds were synthesized from thioureas and include the first sultam thioureas in which the two thiourea nitrogen groups are not identical. In addition, the first X-ray crystal structures of sultam thioureas and the antiviral activity of these compounds against West Nile virus (WNV) are reported.

KW - West Nile virus

KW - antiviral agents

KW - heterocycles

KW - medicinal chemistry

KW - sultam thioureas

KW - thioureas

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ER -

Sultam thioureas: Synthesis and antiviral activity against west nile virus

Abstract

Keywords

ASJC Scopus subject areas

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