Sultam thioureas

Synthesis and antiviral activity against west nile virus

Rachel M. Feeny, Diane N. Le, Joseph W. Parks, Mark G. Epstein, Joseph V. Pagano, Albert C. Abbene, Elaina B. Graham, Joanna R. Farrell, Jason R. McGuire, Robert W. Zoellner, Edward J. Valente, Eric Barklis, Warren J L Wood

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The syntheses of eleven sultam thioureas, including nine new compounds, are described. These compounds were synthesized from thioureas and include the first sultam thioureas in which the two thiourea nitrogen groups are not identical. In addition, the first X-ray crystal structures of sultam thioureas and the antiviral activity of these compounds against West Nile virus (WNV) are reported.

Original languageEnglish (US)
Pages (from-to)301-305
Number of pages5
JournalSynlett
Issue number2
DOIs
StatePublished - 2012

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Thiourea
Viruses
Antiviral Agents
Thermodynamic properties
Nitrogen
Crystal structure
naphthosultone
X rays

Keywords

  • antiviral agents
  • heterocycles
  • medicinal chemistry
  • sultam thioureas
  • thioureas
  • West Nile virus

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Feeny, R. M., Le, D. N., Parks, J. W., Epstein, M. G., Pagano, J. V., Abbene, A. C., ... Wood, W. J. L. (2012). Sultam thioureas: Synthesis and antiviral activity against west nile virus. Synlett, (2), 301-305. https://doi.org/10.1055/s-0031-1290124

Sultam thioureas : Synthesis and antiviral activity against west nile virus. / Feeny, Rachel M.; Le, Diane N.; Parks, Joseph W.; Epstein, Mark G.; Pagano, Joseph V.; Abbene, Albert C.; Graham, Elaina B.; Farrell, Joanna R.; McGuire, Jason R.; Zoellner, Robert W.; Valente, Edward J.; Barklis, Eric; Wood, Warren J L.

In: Synlett, No. 2, 2012, p. 301-305.

Research output: Contribution to journalArticle

Feeny, RM, Le, DN, Parks, JW, Epstein, MG, Pagano, JV, Abbene, AC, Graham, EB, Farrell, JR, McGuire, JR, Zoellner, RW, Valente, EJ, Barklis, E & Wood, WJL 2012, 'Sultam thioureas: Synthesis and antiviral activity against west nile virus', Synlett, no. 2, pp. 301-305. https://doi.org/10.1055/s-0031-1290124
Feeny RM, Le DN, Parks JW, Epstein MG, Pagano JV, Abbene AC et al. Sultam thioureas: Synthesis and antiviral activity against west nile virus. Synlett. 2012;(2):301-305. https://doi.org/10.1055/s-0031-1290124
Feeny, Rachel M. ; Le, Diane N. ; Parks, Joseph W. ; Epstein, Mark G. ; Pagano, Joseph V. ; Abbene, Albert C. ; Graham, Elaina B. ; Farrell, Joanna R. ; McGuire, Jason R. ; Zoellner, Robert W. ; Valente, Edward J. ; Barklis, Eric ; Wood, Warren J L. / Sultam thioureas : Synthesis and antiviral activity against west nile virus. In: Synlett. 2012 ; No. 2. pp. 301-305.
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