Sultam thiourea inhibition of West Nile virus

Eric Barklis, Amelia Still, Mohammad I. Sabri, Alec J. Hirsch, Janko Nikolich-Zugich, James Brien, Tenzin Choesang Dhenub, Isabel Scholz, Ayna Alfadhli

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

We have identified sultam thioureas as novel inhibitors of West Nile virus (WNV) replication. One such compound inhibited WNV, with a 50% effective concentration of 0.7 μM, and reduced reporter expression from cells that harbored a WNV-based replicon. Our results demonstrate that sultam thioureas can block a postentry, preassembly step of WNV replication.

Original languageEnglish (US)
Pages (from-to)2642-2645
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume51
Issue number7
DOIs
StatePublished - Jul 2007

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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