Sulfonylureas correct trafficking defects of disease-causing ATP-sensitive potassium channels by binding to the channel complex

Medicine & Life Sciences

• Sulfonylurea Receptors 100%
• KATP Channels 83%
• Mutation 30%
• Hypoglycemic Agents 20%
• Kir6.2 channel 18%
• Congenital Hyperinsulinism 16%
• Cell Membrane 15%
• Insulin Secretion 10%
• Membrane Potentials 10%
• Endoplasmic Reticulum 10%
• Pharmaceutical Preparations 9%
• Binding Sites 8%
• Type 2 Diabetes Mellitus 8%
• Glucose 6%
• Proteins 4%

Chemical Compounds

• Mutation 55%
• Oral Antidiabetic Agent 21%
• Antidiabetic Agent 16%
• Drug Target 14%
• Membrane Potential 14%
• Insulin Derivative 13%
• Metabolic 10%
• Binding Site 9%
• Surface 8%
• Plasma 8%
• Drug 6%
• Protein 5%