Sugammadex: Pharmacometrics, Clinical Utility, and Adverse Effects

Research output: Contribution to journalArticlepeer-review

Abstract

Sugammadex has been used clinically since 2008, and it represents the only cyclodextrin neuromuscular blocking reversal agent currently available for patient care. Sugammadex's unique mechanism of action allows it to reverse the effects of aminosteroid neuromuscular blockade rapidly, and pharmacodynamically predictable doses are selected based on quantitative neuromuscular monitoring. The drug has several potential adverse effects, predominantly related to immediate hypersensitivity reactions and bradyarrhythmias, and it can be costly. Overall, when employed appropriately, it represents an efficacious addition to the perioperative pharmaceutical armamentarium with significant utility.

Original languageEnglish (US)
Pages (from-to)133-140
Number of pages8
JournalAANA journal
Volume90
Issue number2
StatePublished - Apr 1 2022
Externally publishedYes

Keywords

  • Anesthesiology
  • neuromuscular block reversal
  • reversal agent
  • sugammadex

ASJC Scopus subject areas

  • Medical–Surgical
  • Advanced and Specialized Nursing
  • Anesthesiology and Pain Medicine

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