Purpose: To determine the dose resolution and spatial stability of PRESAGE™, a new three‐dimensional (3D) polyurethane dosimeter. Methods and Materials: PRESAGE™ dosimeters were irradiated to doses between 0.5 Gy and 10 Gy using stereotactic beams to develop a dose response curve and determine the dose resolution. A PRESAGE™ dosimeter was also placed in a water tank with the top surface coincident with the water surface and irradiated using a half‐blocked field delivered by a linear accelerator to investigate the spatial integrity of the dose distribution. An additional PRESAGE™ was irradiated in a similar fashion; however the total dose was delivered in 3 fractions given over 3 days in order to investigate the affect of fractionation on spatial stability. All dosimeters were scanned using an OCT‐OPUS™ laser CT scanner. Results: The PRESAGE™ dosimeter showed a monotonic and easily characterized response with dose. The dose resolution, determined at the 95% confidence level, was found to be comparable to polymer gel formulations. The width of the measured penumbra was 3.98 mm when irradiated in a single fraction and 4.23 mm when irradiated in multiple fractions. Neither dosimeter demonstrated a dose overshoot near the steep dose gradient. Conclusions: This work demonstrated the potential for PRESAGE™ to be used for 3D dosimetry. The dose distributions were found to be spatially stable in high‐dose gradient regions. Also, the dosimeter did not exhibit the dose overshoot often observed with polymer gel dosimeters. Further work is required to optimize the dose resolution of the dosimeter. The investigation was supported by PHS grants CA 10953 awarded by the NCI, DHHS.
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging