Sudden unexpected death in early childhood: general observations in a series of 151 cases: Part 1 of the investigations of the San Diego SUDC Research Project

Marco M. Hefti, Hannah C. Kinney, Jane B. Cryan, Elisabeth A. Haas, Amy E. Chadwick, Laura A. Crandall, Felicia L. Trachtenberg, Dawna D. Armstrong, Marjorie Grafe, Henry F. Krous

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Purpose: The purpose of this study was to determine the major subcategories and clinicopathologic features of sudden unexpected death in young children in a large retrospective cohort, and to confirm the association of sudden unexplained death in children (abbreviated by us for unexplained deaths as SUDC) with hippocampal pathology and/or febrile seizures. Methods: We undertook analysis of a retrospective cohort of 151 cases, of which 80 % (121/151) were subclassified as SUDC, 11 % (16/151) as explained, 7 % (10/151) as undetermined, and 3 % (4/151) as seizure-related. Results: There were no significant differences between SUDC and explained cases in postnatal, gestational, or postconceptional age, frequency of preterm birth, gender, race, or organ weights. In contrast, 96.7 % (117/121) of the SUDC group were discovered during a sleep period compared to 53.3 % (8/15) of the explained group (p 

Original languageEnglish (US)
Pages (from-to)4-13
Number of pages10
JournalForensic Science, Medicine, and Pathology
Volume12
Issue number1
DOIs
StatePublished - Mar 1 2016

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Sudden Death
Febrile Seizures
Organ Size
Premature Birth
Research
Sleep
Seizures
Pathology

Keywords

  • Febrile seizures
  • Hippocampus
  • Sudden death
  • Sudden unexpected death in childhood

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Sudden unexpected death in early childhood : general observations in a series of 151 cases: Part 1 of the investigations of the San Diego SUDC Research Project. / Hefti, Marco M.; Kinney, Hannah C.; Cryan, Jane B.; Haas, Elisabeth A.; Chadwick, Amy E.; Crandall, Laura A.; Trachtenberg, Felicia L.; Armstrong, Dawna D.; Grafe, Marjorie; Krous, Henry F.

In: Forensic Science, Medicine, and Pathology, Vol. 12, No. 1, 01.03.2016, p. 4-13.

Research output: Contribution to journalArticle

Hefti, Marco M. ; Kinney, Hannah C. ; Cryan, Jane B. ; Haas, Elisabeth A. ; Chadwick, Amy E. ; Crandall, Laura A. ; Trachtenberg, Felicia L. ; Armstrong, Dawna D. ; Grafe, Marjorie ; Krous, Henry F. / Sudden unexpected death in early childhood : general observations in a series of 151 cases: Part 1 of the investigations of the San Diego SUDC Research Project. In: Forensic Science, Medicine, and Pathology. 2016 ; Vol. 12, No. 1. pp. 4-13.
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