Succinylated Apoptolidins from Amycolatopsis sp. ICBB 8242

Yan Sheng, Serge Fotso, Jeffrey D. Serrill, Salmah Shahab, Dwi Andreas Santosa, Jane E. Ishmael, Philip J. Proteau, T. Mark Zabriskie, Taifo Mahmud

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Two new apoptolidins, 2′-O-succinyl-apoptolidin A (11) and 3′-O-succinyl-apoptolidin A (12), were isolated from the culture broth of an Indonesian Amycolatopsis sp. ICBB 8242. These compounds inhibit the proliferation and viability of human H292 and HeLa cells. However, in contrast to apoptolidin A (1), they do not inhibit cellular respiration in H292 cells. It is proposed that apoptolidins are produced and secreted in their succinylated forms and 1 is the hydrolysis product of 11 and 12. (Figure Presented).

Original languageEnglish (US)
Pages (from-to)2526-2529
Number of pages4
JournalOrganic Letters
Volume17
Issue number10
DOIs
StatePublished - May 15 2015

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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    Sheng, Y., Fotso, S., Serrill, J. D., Shahab, S., Santosa, D. A., Ishmael, J. E., Proteau, P. J., Zabriskie, T. M., & Mahmud, T. (2015). Succinylated Apoptolidins from Amycolatopsis sp. ICBB 8242. Organic Letters, 17(10), 2526-2529. https://doi.org/10.1021/acs.orglett.5b01055