Succinylated Apoptolidins from Amycolatopsis sp. ICBB 8242

Yan Sheng; Serge Fotso; Jeffrey D. Serrill; Salmah Shahab; Dwi Andreas Santosa; Jane E. Ishmael; Philip J. Proteau; T. Mark Zabriskie; Taifo Mahmud

doi:10.1021/acs.orglett.5b01055

Succinylated Apoptolidins from Amycolatopsis sp. ICBB 8242

Yan Sheng, Serge Fotso, Jeffrey D. Serrill, Salmah Shahab, Dwi Andreas Santosa, Jane E. Ishmael, Philip J. Proteau, T. Mark Zabriskie, Taifo Mahmud

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Two new apoptolidins, 2′-O-succinyl-apoptolidin A (11) and 3′-O-succinyl-apoptolidin A (12), were isolated from the culture broth of an Indonesian Amycolatopsis sp. ICBB 8242. These compounds inhibit the proliferation and viability of human H292 and HeLa cells. However, in contrast to apoptolidin A (1), they do not inhibit cellular respiration in H292 cells. It is proposed that apoptolidins are produced and secreted in their succinylated forms and 1 is the hydrolysis product of 11 and 12. (Figure Presented).

Original language	English (US)
Pages (from-to)	2526-2529
Number of pages	4
Journal	Organic Letters
Volume	17
Issue number	10
DOIs	https://doi.org/10.1021/acs.orglett.5b01055
State	Published - May 15 2015
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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title = "Succinylated Apoptolidins from Amycolatopsis sp. ICBB 8242",

abstract = "Two new apoptolidins, 2′-O-succinyl-apoptolidin A (11) and 3′-O-succinyl-apoptolidin A (12), were isolated from the culture broth of an Indonesian Amycolatopsis sp. ICBB 8242. These compounds inhibit the proliferation and viability of human H292 and HeLa cells. However, in contrast to apoptolidin A (1), they do not inhibit cellular respiration in H292 cells. It is proposed that apoptolidins are produced and secreted in their succinylated forms and 1 is the hydrolysis product of 11 and 12. (Figure Presented).",

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doi = "10.1021/acs.orglett.5b01055",

language = "English (US)",

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T1 - Succinylated Apoptolidins from Amycolatopsis sp. ICBB 8242

AU - Sheng, Yan

AU - Fotso, Serge

AU - Serrill, Jeffrey D.

AU - Shahab, Salmah

AU - Santosa, Dwi Andreas

AU - Ishmael, Jane E.

AU - Proteau, Philip J.

AU - Zabriskie, T. Mark

AU - Mahmud, Taifo

PY - 2015/5/15

Y1 - 2015/5/15

N2 - Two new apoptolidins, 2′-O-succinyl-apoptolidin A (11) and 3′-O-succinyl-apoptolidin A (12), were isolated from the culture broth of an Indonesian Amycolatopsis sp. ICBB 8242. These compounds inhibit the proliferation and viability of human H292 and HeLa cells. However, in contrast to apoptolidin A (1), they do not inhibit cellular respiration in H292 cells. It is proposed that apoptolidins are produced and secreted in their succinylated forms and 1 is the hydrolysis product of 11 and 12. (Figure Presented).

AB - Two new apoptolidins, 2′-O-succinyl-apoptolidin A (11) and 3′-O-succinyl-apoptolidin A (12), were isolated from the culture broth of an Indonesian Amycolatopsis sp. ICBB 8242. These compounds inhibit the proliferation and viability of human H292 and HeLa cells. However, in contrast to apoptolidin A (1), they do not inhibit cellular respiration in H292 cells. It is proposed that apoptolidins are produced and secreted in their succinylated forms and 1 is the hydrolysis product of 11 and 12. (Figure Presented).

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Succinylated Apoptolidins from Amycolatopsis sp. ICBB 8242

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