Succinate oxidation in rat liver mitochondria in vitamin E deficiency

Anuradha Pappu, P. Fatterpakar, A. Sreenivasan

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The respiratory decline observed in vitamin E-deficient mitonchondria is not due to alterations either in the content of cytochromes or in the activity of succinate dehydrogenase. There is a decrease in the ratio of DNP-stimulated to Mg2+-activated ATPase of liver mitonchondria in the deficiency condition, indicative of membrane damage. Addition of lysolecithin to liver mitochondria from control rats does not affect succinoxidase activity per se, however it can alter the response of ATPase to DNP and Mg2+. The increased lysolecithin content of mitochondria in vitamin E-deficiency could probably cause respiratory decline indirectly through membrane damage.

Original languageEnglish (US)
Pages (from-to)48-50
Number of pages3
JournalIndian Journal of Biochemistry and Biophysics
Volume17
Issue number1
StatePublished - 1980
Externally publishedYes

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Vitamin E Deficiency
Lysophosphatidylcholines
Mitochondria
Liver Mitochondrion
Succinic Acid
Vitamin E
Liver
Adenosine Triphosphatases
Rats
Rat control
Membranes
Ca(2+) Mg(2+)-ATPase
Oxidation
Succinate Dehydrogenase
Cytochromes
succinate oxidase

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics

Cite this

Succinate oxidation in rat liver mitochondria in vitamin E deficiency. / Pappu, Anuradha; Fatterpakar, P.; Sreenivasan, A.

In: Indian Journal of Biochemistry and Biophysics, Vol. 17, No. 1, 1980, p. 48-50.

Research output: Contribution to journalArticle

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