Successful treatment of optic neuropathy in association with systemic lupus erythematosus using intravenous cyclophosphamide

James T. Rosenbaum, Jennifer Simpson, C. Michael Neuwelt

Research output: Contribution to journalArticle

32 Scopus citations


Background - Optic neuropathy is a rare manifestation of systemic lupus erythematosus (SLE). In a previous series most patients with optic neuropathy in association with SLE had a final visual acuity of 20/200 or less despite corticosteroid therapy. Methods - Three patients (five affected eyes) with severe retrobulbar optic neuropathy in association with SLE were treated promptly with intravenous cyclophosphamide and corticosteroids. Results - All patients recovered excellent visual acuity. Conclusion - Although optic neuropathy in association with SLE might have several different aetiologies, intravenous cyclophosphamide should be strongly considered as a therapeutic alternative.

Original languageEnglish (US)
Pages (from-to)130-132
Number of pages3
JournalBritish Journal of Ophthalmology
Issue number2
StatePublished - Feb 1997


ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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