Successful treatment of Fusarium endophthalmitis with voriconazole and Aspergillus endophthalmitis with voriconazole plus caspofungin

Marlene L. Durand; Ivana K. Kim; Donald J. D'Amico; John I. Loewenstein; Ellis H. Tobin; Shalom J. Kieval; Stephen S. Martin; Dimitri T. Azar; Frederick S. Miller; Brandon J. Lujan; Joan W. Miller

doi:10.1016/j.ajo.2005.03.030

Successful treatment of Fusarium endophthalmitis with voriconazole and Aspergillus endophthalmitis with voriconazole plus caspofungin

Marlene L. Durand, Ivana K. Kim, Donald J. D'Amico, John I. Loewenstein, Ellis H. Tobin, Shalom J. Kieval, Stephen S. Martin, Dimitri T. Azar, Frederick S. Miller, Brandon J. Lujan, Joan W. Miller

Research output: Contribution to journal › Article › peer-review

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Abstract

PURPOSE: To report successful treatment of exogenous Fusarium and Aspergillus endophthalmitis with new antifungal agents. DESIGN: Interventional case report. METHODS: Treatment of two cases is reviewed. RESULTS: A 64-year-old man developed post-cataract Fusarium moniliforme endophthalmitis. Infection persisted despite removal of the intraocular lens, three vitrectomies, and five intravitreal injections of amphotericin. Inflammation resolved and vision improved from 20/80 to 20/40 on 6 months of oral voriconazole. A 55-year-old man developed post-cataract intraocular inflammation. After three vitrectomies and removal of the intraocular lens, Aspergillus fumigatus endophthalmitis was diagnosed. Intravitreal amphotericin and systemic voriconazole were given, but one week later there were early signs of recurrence. Intravenous caspofungin was added and the eye improved. Caspofungin was continued for 6 weeks and voriconazole for 6 months. Vision improved from counting fingers to 20/80 at 6 months and 20/25 at 23 months. CONCLUSION: Voriconazole is a promising new therapy for Fusarium and Aspergillus endophthalmitis. Caspofungin may act synergistically with voriconazole in treating Aspergillus endophthalmitis.

Original language	English (US)
Pages (from-to)	552-554
Number of pages	3
Journal	American journal of ophthalmology
Volume	140
Issue number	3
DOIs	https://doi.org/10.1016/j.ajo.2005.03.030
State	Published - Sep 2005
Externally published	Yes

ASJC Scopus subject areas

Ophthalmology

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Durand, M. L., Kim, I. K., D'Amico, D. J., Loewenstein, J. I., Tobin, E. H., Kieval, S. J., Martin, S. S., Azar, D. T., Miller, F. S., Lujan, B. J., & Miller, J. W. (2005). Successful treatment of Fusarium endophthalmitis with voriconazole and Aspergillus endophthalmitis with voriconazole plus caspofungin. American journal of ophthalmology, 140(3), 552-554. https://doi.org/10.1016/j.ajo.2005.03.030

Durand, ML, Kim, IK, D'Amico, DJ, Loewenstein, JI, Tobin, EH, Kieval, SJ, Martin, SS, Azar, DT, Miller, FS, Lujan, BJ & Miller, JW 2005, 'Successful treatment of Fusarium endophthalmitis with voriconazole and Aspergillus endophthalmitis with voriconazole plus caspofungin', American journal of ophthalmology, vol. 140, no. 3, pp. 552-554. https://doi.org/10.1016/j.ajo.2005.03.030

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title = "Successful treatment of Fusarium endophthalmitis with voriconazole and Aspergillus endophthalmitis with voriconazole plus caspofungin",

abstract = "PURPOSE: To report successful treatment of exogenous Fusarium and Aspergillus endophthalmitis with new antifungal agents. DESIGN: Interventional case report. METHODS: Treatment of two cases is reviewed. RESULTS: A 64-year-old man developed post-cataract Fusarium moniliforme endophthalmitis. Infection persisted despite removal of the intraocular lens, three vitrectomies, and five intravitreal injections of amphotericin. Inflammation resolved and vision improved from 20/80 to 20/40 on 6 months of oral voriconazole. A 55-year-old man developed post-cataract intraocular inflammation. After three vitrectomies and removal of the intraocular lens, Aspergillus fumigatus endophthalmitis was diagnosed. Intravitreal amphotericin and systemic voriconazole were given, but one week later there were early signs of recurrence. Intravenous caspofungin was added and the eye improved. Caspofungin was continued for 6 weeks and voriconazole for 6 months. Vision improved from counting fingers to 20/80 at 6 months and 20/25 at 23 months. CONCLUSION: Voriconazole is a promising new therapy for Fusarium and Aspergillus endophthalmitis. Caspofungin may act synergistically with voriconazole in treating Aspergillus endophthalmitis.",

author = "Durand, {Marlene L.} and Kim, {Ivana K.} and D'Amico, {Donald J.} and Loewenstein, {John I.} and Tobin, {Ellis H.} and Kieval, {Shalom J.} and Martin, {Stephen S.} and Azar, {Dimitri T.} and Miller, {Frederick S.} and Lujan, {Brandon J.} and Miller, {Joan W.}",

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doi = "10.1016/j.ajo.2005.03.030",

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T1 - Successful treatment of Fusarium endophthalmitis with voriconazole and Aspergillus endophthalmitis with voriconazole plus caspofungin

AU - Durand, Marlene L.

AU - Kim, Ivana K.

AU - D'Amico, Donald J.

AU - Loewenstein, John I.

AU - Tobin, Ellis H.

AU - Kieval, Shalom J.

AU - Martin, Stephen S.

AU - Azar, Dimitri T.

AU - Miller, Frederick S.

AU - Lujan, Brandon J.

AU - Miller, Joan W.

PY - 2005/9

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N2 - PURPOSE: To report successful treatment of exogenous Fusarium and Aspergillus endophthalmitis with new antifungal agents. DESIGN: Interventional case report. METHODS: Treatment of two cases is reviewed. RESULTS: A 64-year-old man developed post-cataract Fusarium moniliforme endophthalmitis. Infection persisted despite removal of the intraocular lens, three vitrectomies, and five intravitreal injections of amphotericin. Inflammation resolved and vision improved from 20/80 to 20/40 on 6 months of oral voriconazole. A 55-year-old man developed post-cataract intraocular inflammation. After three vitrectomies and removal of the intraocular lens, Aspergillus fumigatus endophthalmitis was diagnosed. Intravitreal amphotericin and systemic voriconazole were given, but one week later there were early signs of recurrence. Intravenous caspofungin was added and the eye improved. Caspofungin was continued for 6 weeks and voriconazole for 6 months. Vision improved from counting fingers to 20/80 at 6 months and 20/25 at 23 months. CONCLUSION: Voriconazole is a promising new therapy for Fusarium and Aspergillus endophthalmitis. Caspofungin may act synergistically with voriconazole in treating Aspergillus endophthalmitis.

AB - PURPOSE: To report successful treatment of exogenous Fusarium and Aspergillus endophthalmitis with new antifungal agents. DESIGN: Interventional case report. METHODS: Treatment of two cases is reviewed. RESULTS: A 64-year-old man developed post-cataract Fusarium moniliforme endophthalmitis. Infection persisted despite removal of the intraocular lens, three vitrectomies, and five intravitreal injections of amphotericin. Inflammation resolved and vision improved from 20/80 to 20/40 on 6 months of oral voriconazole. A 55-year-old man developed post-cataract intraocular inflammation. After three vitrectomies and removal of the intraocular lens, Aspergillus fumigatus endophthalmitis was diagnosed. Intravitreal amphotericin and systemic voriconazole were given, but one week later there were early signs of recurrence. Intravenous caspofungin was added and the eye improved. Caspofungin was continued for 6 weeks and voriconazole for 6 months. Vision improved from counting fingers to 20/80 at 6 months and 20/25 at 23 months. CONCLUSION: Voriconazole is a promising new therapy for Fusarium and Aspergillus endophthalmitis. Caspofungin may act synergistically with voriconazole in treating Aspergillus endophthalmitis.

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Successful treatment of Fusarium endophthalmitis with voriconazole and Aspergillus endophthalmitis with voriconazole plus caspofungin

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