Successful repair of esophageal injury using elastin based biomaterial patch

Michio Kajitani, Yasmin Wadia, Monica Hinds, Jeffrey Teach, Kim Swartz, Kenton Gregory

Research output: Contribution to journalArticle

Abstract

In vivo study was conducted to test an elastin based biomaterial patch composed of elastin and collagen to repair the large tissue defect in the esophagus. Ten domestic pigs underwent right thoracotomy. A 2 cm circular defect made on the distal esophagus was repaired using the elastin based biomaterial patch and running absorbable sutures. Soon after closure and extubation, the animals were followed to resume oral feeding. The animals were followed for clinical status, weight gain, and endoscopic studies. They were electively sacrificed after six weeks to four months. The results indicate that the Elastin based biomaterial patch can be used safely and reliably for repair of esophageal injury with significant tissue loss. Complete regeneration of the esophageal wall was observed when repaired immediately after the injury in the experiment.

Original languageEnglish (US)
Pages (from-to)226
Number of pages1
JournalASAIO Journal
Volume46
Issue number2
StatePublished - Mar 2000

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Elastin
Biocompatible Materials
Biomaterials
Repair
Wounds and Injuries
Esophagus
Animals
Tissue
Sus scrofa
Defects
Thoracotomy
Collagen
Running
Sutures
Weight Gain
Regeneration
Experiments

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering

Cite this

Successful repair of esophageal injury using elastin based biomaterial patch. / Kajitani, Michio; Wadia, Yasmin; Hinds, Monica; Teach, Jeffrey; Swartz, Kim; Gregory, Kenton.

In: ASAIO Journal, Vol. 46, No. 2, 03.2000, p. 226.

Research output: Contribution to journalArticle

Kajitani, M, Wadia, Y, Hinds, M, Teach, J, Swartz, K & Gregory, K 2000, 'Successful repair of esophageal injury using elastin based biomaterial patch', ASAIO Journal, vol. 46, no. 2, pp. 226.
Kajitani, Michio ; Wadia, Yasmin ; Hinds, Monica ; Teach, Jeffrey ; Swartz, Kim ; Gregory, Kenton. / Successful repair of esophageal injury using elastin based biomaterial patch. In: ASAIO Journal. 2000 ; Vol. 46, No. 2. pp. 226.
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