Successful repair of esophageal injury using elastin based biomaterial patch

Michio Kajitani; Yasmin Wadia; Monica T. Hinds; Jeffrey Teach; Kim Swartz; Kenton G. Gregory

doi:10.1097/00002480-200003000-00300

Successful repair of esophageal injury using elastin based biomaterial patch

Michio Kajitani, Yasmin Wadia, Monica T. Hinds, Jeffrey Teach, Kim Swartz, Kenton G. Gregory

Research output: Contribution to journal › Conference article › peer-review

Abstract

In vivo study was conducted to test an elastin based biomaterial patch composed of elastin and collagen to repair the large tissue defect in the esophagus. Ten domestic pigs underwent right thoracotomy. A 2 cm circular defect made on the distal esophagus was repaired using the elastin based biomaterial patch and running absorbable sutures. Soon after closure and extubation, the animals were followed to resume oral feeding. The animals were followed for clinical status, weight gain, and endoscopic studies. They were electively sacrificed after six weeks to four months. The results indicate that the Elastin based biomaterial patch can be used safely and reliably for repair of esophageal injury with significant tissue loss. Complete regeneration of the esophageal wall was observed when repaired immediately after the injury in the experiment.

Original language	English (US)
Number of pages	1
Journal	ASAIO Journal
Volume	46
Issue number	2
DOIs	https://doi.org/10.1097/00002480-200003000-00300
State	Published - Jan 1 2000
Event	46th Annual Conference and Exposition of ASAIO - New York, NY, USA Duration: Jun 28 2000 → Jul 1 2000

ASJC Scopus subject areas

Biophysics
Bioengineering
Biomaterials
Biomedical Engineering

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10.1097/00002480-200003000-00300

Cite this

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title = "Successful repair of esophageal injury using elastin based biomaterial patch",

abstract = "In vivo study was conducted to test an elastin based biomaterial patch composed of elastin and collagen to repair the large tissue defect in the esophagus. Ten domestic pigs underwent right thoracotomy. A 2 cm circular defect made on the distal esophagus was repaired using the elastin based biomaterial patch and running absorbable sutures. Soon after closure and extubation, the animals were followed to resume oral feeding. The animals were followed for clinical status, weight gain, and endoscopic studies. They were electively sacrificed after six weeks to four months. The results indicate that the Elastin based biomaterial patch can be used safely and reliably for repair of esophageal injury with significant tissue loss. Complete regeneration of the esophageal wall was observed when repaired immediately after the injury in the experiment.",

author = "Michio Kajitani and Yasmin Wadia and Hinds, {Monica T.} and Jeffrey Teach and Kim Swartz and Gregory, {Kenton G.}",

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TY - JOUR

T1 - Successful repair of esophageal injury using elastin based biomaterial patch

AU - Kajitani, Michio

AU - Wadia, Yasmin

AU - Hinds, Monica T.

AU - Teach, Jeffrey

AU - Swartz, Kim

AU - Gregory, Kenton G.

PY - 2000/1/1

Y1 - 2000/1/1

N2 - In vivo study was conducted to test an elastin based biomaterial patch composed of elastin and collagen to repair the large tissue defect in the esophagus. Ten domestic pigs underwent right thoracotomy. A 2 cm circular defect made on the distal esophagus was repaired using the elastin based biomaterial patch and running absorbable sutures. Soon after closure and extubation, the animals were followed to resume oral feeding. The animals were followed for clinical status, weight gain, and endoscopic studies. They were electively sacrificed after six weeks to four months. The results indicate that the Elastin based biomaterial patch can be used safely and reliably for repair of esophageal injury with significant tissue loss. Complete regeneration of the esophageal wall was observed when repaired immediately after the injury in the experiment.

AB - In vivo study was conducted to test an elastin based biomaterial patch composed of elastin and collagen to repair the large tissue defect in the esophagus. Ten domestic pigs underwent right thoracotomy. A 2 cm circular defect made on the distal esophagus was repaired using the elastin based biomaterial patch and running absorbable sutures. Soon after closure and extubation, the animals were followed to resume oral feeding. The animals were followed for clinical status, weight gain, and endoscopic studies. They were electively sacrificed after six weeks to four months. The results indicate that the Elastin based biomaterial patch can be used safely and reliably for repair of esophageal injury with significant tissue loss. Complete regeneration of the esophageal wall was observed when repaired immediately after the injury in the experiment.

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T2 - 46th Annual Conference and Exposition of ASAIO

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Successful repair of esophageal injury using elastin based biomaterial patch

Abstract

ASJC Scopus subject areas

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