Successful repair of esophageal injury using elastin based biomaterial patch

Michio Kajitani, Yasmin Wadia, Monica T. Hinds, Jeffrey Teach, Kim Swartz, Kenton G. Gregory

Research output: Contribution to journalConference article

Abstract

In vivo study was conducted to test an elastin based biomaterial patch composed of elastin and collagen to repair the large tissue defect in the esophagus. Ten domestic pigs underwent right thoracotomy. A 2 cm circular defect made on the distal esophagus was repaired using the elastin based biomaterial patch and running absorbable sutures. Soon after closure and extubation, the animals were followed to resume oral feeding. The animals were followed for clinical status, weight gain, and endoscopic studies. They were electively sacrificed after six weeks to four months. The results indicate that the Elastin based biomaterial patch can be used safely and reliably for repair of esophageal injury with significant tissue loss. Complete regeneration of the esophageal wall was observed when repaired immediately after the injury in the experiment.

Original languageEnglish (US)
Number of pages1
JournalASAIO Journal
Volume46
Issue number2
DOIs
StatePublished - Jan 1 2000
Event46th Annual Conference and Exposition of ASAIO - New York, NY, USA
Duration: Jun 28 2000Jul 1 2000

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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