In vivo study was conducted to test an elastin based biomaterial patch composed of elastin and collagen to repair the large tissue defect in the esophagus. Ten domestic pigs underwent right thoracotomy. A 2 cm circular defect made on the distal esophagus was repaired using the elastin based biomaterial patch and running absorbable sutures. Soon after closure and extubation, the animals were followed to resume oral feeding. The animals were followed for clinical status, weight gain, and endoscopic studies. They were electively sacrificed after six weeks to four months. The results indicate that the Elastin based biomaterial patch can be used safely and reliably for repair of esophageal injury with significant tissue loss. Complete regeneration of the esophageal wall was observed when repaired immediately after the injury in the experiment.
ASJC Scopus subject areas
- Biomedical Engineering