Successful engraftment of human hepatocytes in uPA- SCID and FRG® KO mice

Lander Foquet, Elizabeth M. Wilson, Lieven Verhoye, Markus Grompe, Geert Leroux-Roels, John Bial, Philip Meuleman

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations

Abstract

Mice with humanized chimeric liver are promising in vivo tools to evaluate the efficacy of novel compounds or vaccine induced antibodies directed against pathogens that infect the human liver. In addition they can be used to study the human-type metabolism of medicinal compounds and hepatotoxicity.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages117-130
Number of pages14
Volume1506
DOIs
StatePublished - 2017

Publication series

NameMethods in Molecular Biology
Volume1506
ISSN (Print)10643745

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Keywords

  • Humanized mouse model
  • In vivo
  • Liver
  • Malaria
  • Metabolism
  • Plasmodium falciparum
  • Viral hepatitis

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Foquet, L., Wilson, E. M., Verhoye, L., Grompe, M., Leroux-Roels, G., Bial, J., & Meuleman, P. (2017). Successful engraftment of human hepatocytes in uPA- SCID and FRG® KO mice. In Methods in Molecular Biology (Vol. 1506, pp. 117-130). (Methods in Molecular Biology; Vol. 1506). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-6506-9_8